The effect of oral administration of Folus (Cassia fistula( fruit aqueous extract on abomasal emptying rate in neonatal lambs

Subject Areas : Veterinary Clinical Pathology

Mostafa  Abdollahi ¹ (Post Graduate Student of Large Animals Internal Medicine, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran.)
Hamidreza  Mohammadi ² (Asistant Professor, Department of Clinical Science, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran.)
Mahmood  Ahmadi Hamedani ³ (Asistant Professor, Department of Clinical Science, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran.)
Morteza  Abdollahi ⁴ (DVM Graduate, Faculty of Veterinary Medicine, Garmsar Branch, Islamic Azad University, Garmsar, Iran.)
Vahid  Shahbazi ⁵ (DVM Graduate, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran.)

Received: 2018-04-10 Accepted : 2018-11-04 Published : 2019-04-21

Keywords: lamb, Spectrophotometry, Abomasum, Cassia fistula fruit,

Abstract :

Abomasal hypomotility plays an important role in the pathogenesis of certain abomasal disorders such as abomasal bloat. Serious side effects such as diarrhea and antibiotic resistance are associated with using synthetic drugs for treatment of these disorders and administration of herbal medicine could be an appropriate approach to decrease these side effects. Therefore the goal of this study was to evaluate the effect of Folus fruit aqueous extracton abomasal emptying in lambs. This study was conducted on twelve five-day-old Sangsari-female-lambs (average weight 4 kg). Lambs received five oral treatments including saline (30 ml), erythromycin (400 mg) and folus at three different doses (700, 750 and 800 mg/kg) respectively. Acetaminophen absorption test was used to evaluate the rate of abomasal emptying. After drawing the association curve  between plasma acetaminophen concentration and time using the regression method, it was indicated that treatment with erythromycin and three different doses of aqueous extract of folus fruit (700, 750, 800 mg/kg) significantly increased the rate of abomasal emptying in comparison to the negative control (p < /em><0.05). No clinical side effects were observed following the administration of erythromycin and folus in lambs. This study showed that aqueous extract of folus fruit has a stimulatory effect on abomasal emptying in lambs but further studies are required to determine the effects of various components of this plant on abomasal emptying.

References:

• Agrawal, K., Ghildiyal, S., Gautam, M.K., Joshi, V.K. and Goel, R.K. (2012). Studies on laxative effect of extract of dried fruit pulp of Cassia fistula. Journal of Natural Remedies, 12(2): 119-128.


• Akanmu, M.A., Iwalewa, E.O., Elujoba, A.A. and Adelusola K.A. (2004). Toxicity potentials of Cassia fistula fruits as laxative with reference to SENNA. African Journal of Biomedical Research, 7: 23-26.


• Bahorun, T., Neergheen, V.S. and Aruoma, O.I. (2005). Phytochemical constituents of Cassia fistula. African Journal of Biotechnology, 4(13): 1530-1540.


• Bakkali, F., Averbeck, S., Averbeck, D. and Idaomar, M. (2008). Biological effects of essential oils–a review. Food and Chemical Toxicology, 46(2): 446-475.


• Cabral, A., Cornejo, M.P, Fernandez, G., De-Francesco, P.N., Garcia-Romero, G., Uriarte, M., et al. (2017). Circulating Ghrelin Acts on GABA neurons of the area postrema and mediates gastric emptying in male mice. Endocrinology, 158(5): 1436-1449.


• Chandra, R., Liu, P., Breen, J.D., Fisher, J., Xie, C., LaBadie, R., et al. (2007). Clinical pharmacokinetics and gastrointestinal tolerability of a novel extended-release microsphere formulation of azithromycin. Clinical Pharmacokinetics, 46(3): 247-259.


• Daisy, P., Balasubramanian, K., Rajalakshmi, M., Eliza, J. and Selvaraj, J. (2010). Insulin mimetic impact of Catechin isolated from Cassia fistula on the glucose oxidation and molecular mechanisms of glucose uptake on Streptozotocin-induced diabetic Wistar rats. Phytomedicine, 17(1): 28-36.


• Duraipandiyan, V. and Ignacimuthu, S. (2007). Antibacterial and antifungal activity of Cassia fistula L.: An ethnomedicinal plant. Journal of Ethnopharmacology, 112: 590-594.


• Gershon, M.D. and Tack, J. (2007). The serotonin signaling system: from basic understanding to drug development for functional GI disorders. Gastroenterology, 132(1): 397-414.


• Ilavarasan, R., Mallika, M. and Venkataraman, S. (2005). Anti-inflammatory and antioxidant activities of Cassai fistula Linn bark extracts. African Journal of Traditional, Complementary and Alternative Medicines, 2(1): 70-85.


• Jaffary, F., Nilforoushzadeh, M.A., Ansari, N. and Rahimi, M. (2010). Treatment of cutaneous leishmaniasis: cassia fistula fruit gel-intralesionl glucantime Vs. placebo gel-intralesional glucantime combination. Tehran University Medical Journal, 67(10): 705-711. [In Persian]


• Marshall, T.S., Constable, P.D., Crochik, S.S. and Wittek, T. (2005). Determination of abomasal emptying rate in suckling calves by use of nuclear scintigraphy and acetaminophen absorption. American Journal of Veterinary Research, 66(3): 364-374.


• Michel, A., Mevissen, M., Burkhardt, H. and Steiner, A. (2003). In vitro effects of cisapride, metoclopramide and bethanechol on smooth muscle preparations from abomasal antrum and duodenum of dairy cows. Journal of Veterinary Pharmacology and Therapeutics, 26(6): 413-420.


• Nejadsahebi, M., Khaleghiand, E. and Moallemi, N. (2007). Effects of acid and hot water scarification treatments on germination parameters of Delonix regia and Cassia fistula. Journal of Agricultural Sciences and Natural Resources, 14(1): 1-10. [In Persian]


• Noori-Mugahi, S.M.H., Mokhtari, T., Omidi, A. and Takzaree, N. (2014). Effects of L-NAME on morphometric parameters of stomach parietal cells in pregnant rats. Tehran University Medical Journal, 72(2): 65-71. [In Persian]


• Nouri, M. and Constable, P.D. (2007). Effect of parenteral administration of erythromycin, tilmicosin, and tylosin on abomasal emptying rate in suckling calves. American Journal of Veterinary Research, 68(12): 1392-1398.


• Nouri, M., Hajikolaee, M., Constable, P. and Omidi, A. (2008). Effect of erythromycin and gentamicin on abomasal emptying rate in suckling calves. Journal of Veterinary Internal Medicine, 22(1): 196-201.


• Ramaswamy, U., Sivasubramanian, V. and Niranjali Devaraj, S. (2016). In vitro cytotoxic activity of aqueous extract of Chlorococcum humicola and ethylacetate extract of Desmococcus olivaceus on Hep 2 cells of human lung cancer. World Journal of Pharmacy and Pharmaceutical Sciences, 5: 1374-1380.


• Sharifi, K., Grünberg, W., Soroori, S., Mohri, M. and Ahrari-Khafi, M.S. (2009). Assessment of the acetaminophen absorption test as a diagnostic tool for the evaluation of the reticular groove reflex in lambs. American Journal of Veterinary Research, 70(7): 820-825.


• Smith, B.P. (2014). Large Animal Internal Medicine, 5th ed., Edinburgh: Elsevier Health Sciences, pp: 723-725.


• Tachibana, T., Nakai, Y., Makino, R., Islam-khan, M.S. and Cline, M.A. (2017). Effect of central and peripheral injection of prostaglandin E2 and F2α on feeding and the crop-emptying rate in chicks. Prostaglandins and Other Lipid Mediators, 130: 30-37.


• Vafaei, A.A., Miladi-gorgi, H., Moghimi, H.R. and Ameri, M. (2011). The effect of fruit Cassia fistula aqueous extract on sleeping time and the level of anxiety in mice. Journal of Gorgan University of Medical Sciences, 12(4): 1-6. [In Persian]


• Wittek, T. and Constable, P.D. (2005). Assessment of the effects of erythromycin, neostigmine, and metoclopramide on abomasal motility and emptying rate in calves. American Journal of Veterinary Research, 66(3): 545-552.


• Yu, H.S., Lee, S.Y. and Jang, C.G. (2007). Involvement of 5-HT1A and GABAA receptors in the anxiolytic-like effects of Cinnamomm cassia in mice. Pharmacology Biochemistry and Behavior, 87(1): 164-70.