Effect of endurance exercise preconditioning on TrkB levels and some behavioral functions of male rats Cause a stroke

Subject Areas : New studies in exercise metabolism and physical activity

Meysam Fahim ¹ , mostafa teymuri kharvi ²

1 - PhD Student of Exercise Physiology, Department of PhysicalEducation and Sport Science, Bojnourd Branch, Islamic Azad University, Bojnourd, Iran.
2 - Assistant Professor, Department of Physical Education and Sport Science, Bojnourd Branch, Islamic Azad University, Bojnourd, Iran

Received: 2022-08-25 Accepted : 2022-11-15 Published : 2023-05-22

Keywords: Endurance training, Stroke, BDNF, Neurotrophins, TrkB,

Abstract :

AbstractBackground and Objective: A valuable approach to increasing health and reducing brain damage is to use exercise and physical training as a pre-preparation that leads to some molecular cellular changes and improved behavioral functions.Materials and Methods: In this quasi-experimental study, animals were randomly divided into three equal groups of 01, including endurance training, stroke and control. The training protocol in the endurance group included swimming in water for three weeks and five days a week for 01 minutes every day at a water temperature of 03 ± 3 ° C. Rats in the control group and the stroke group spent three weeks without any training. To create the ischemia model, the common carotid artery (CCA) was blocked for 01 minutes with aneurysm clamps. 32hours after ischemia, TrkB enzyme levels were assessed using Real Time Pcr and behavioral functions.Results: There was a significant difference in the TrkB variable between the endurance group and the stroke and control groups in favor of the endurance group (P = 10110). Also, a significant difference was found between the stroke group and the control group (P = 10110).In relation to neurological disorder, a significant difference was observed between the endurance group and the two groups of stroke and control (P = 10110).Conclusion: Aerobic exercise can produce positive neuroprotective effects in relation to neurogenesis by altering TrkB gene expression, which can also be seen in behavioral functions.