The effect of endurance training and consumption of nettle plant extract on immune and inflammatory indicators of diabetic rats treated with streptozotocin.
Subject Areas : Physical Activity and Health
pooya mirzai
1
,
Khalid Mohamadzadeh salamat
2
1 - Master's degree, exercise physiology, Department of Physical Education, Azad University, Sanandaj Branch, Sanandaj, Iran
2 - Department of physical education and sport sciences, sanandaj branch, sanandaj, Iran
Keywords: Exercise, immune system, Type 2 diabetes, nettle plant, systemic inflammation,
Abstract :
The aim of the present study was to investigate the effect of endurance exercise and consumption of nettle extract on immune and inflammatory indicators of diabetic rats treated with streptozotocin. 70 male Sprague-Dawley rats were randomly divided into 7 groups of 10 series, 1- healthy control, 2- diabetic control, 3- nettle, 4- metformin, 5- exercise, 6- nettle + exercise, 7- metformin + exercise. Groups 3 and 6 received nettle extract and 4 and 7 metformin for four weeks; Groups 5-7 did endurance training during this time. At the end of the treatment period, blood samples of mice were taken to measure immune cells, C-reactive protein (CRP), interleukin (IL)-6, IL-2, IL-6, IL-8 and tumor necrosis factor (TNF-α) was collected. The results showed that the nettle, exercise and nettle+exercise groups had the lowest number of neutrophils compared to the diabetic control group. The number of basophils in the metformin group and the number of lymphocytes in the nettle and nettle + exercise groups were significantly lower than the diabetic control group. The concentration of CRP and IL-6 was significantly lower only in nettle + exercise group compared to the diabetic control group. Also, IL-2 and TNF-α in all treatment groups showed lower and significant values compared to the diabetic control group (P<0.05). According to these results, it can be concluded that the use of nettle during aerobic exercise improves the condition of diabetic patients by reducing systemic inflammation and strengthening immune function.
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