Investigation the protective effect of vitamin C and forced swimming activity on glycemic index in male diabetic rats treated with alloxan monohydrate.

Subject Areas : Physical Activity and Health

Ronak Azizbeigi ¹ , Aazam Amiri ² , Mahdieh Raeeszadeh ³

1 - Academic member
2 - Graduated from Faculty Veterinary, Sanandaj Branch, Islamid Azad University , Sanandaj, Iran
3 - Department of Basic Sciences, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran.

Received: 2021-10-14 Accepted : 2022-03-12 Published : 2022-03-21

Keywords:

Abstract :

The aim of this study was to investigate the effect of vitamin C on glycemic indices during forced swimming activity in male diabetic rats treated with alloxan monohydrate. For this purpose, 50 adult male Wistar rats were randomly divided into 5 groups of 10, including the control group, the diabetic group, the diabetic - vitamin C group, diabetic - forced swimming activity group and the diabetic - vitamin C - forced swimming activity group. According to the protocol, forced swimming activity was performed in six sessions (10 to 60 minutes) per week.Blood sampling was done 24 hours after the last interventions, in state fasting and directly from the heart of the animals. The results showed that there is a significant difference between the diabetic - vitamin C - forced swimming group and the control group with the diabetic group, in fasting blood sugar, insulin, glycosylated hemoglobin and insulin resistance. (p≥0.05). Also, a significant difference was observed in insulin levels between the diabetic - forced swimming group, the diabetic - vitamin C group (p=0.035) and the diabetic - forced swimming - vitamin C group (p=0.019).While there was no significant difference between any of the intervention groups in other variables (p>0.05). In general, it can be concluded that although vitamin C and forced swimming were able to moderate and reduce fasting blood sugar in diabetic rats, despite this, the combination of these two factors will not bring more benefits.Key words: vitamin C, forced swimming activity, diabetes, alloxan monohydrate, male rat