The effect of a regular exercise course with vitamin B6 and omega-3 consumption on NF-KB gene expression of endometrial tissue in endometriosis model rats

Subject Areas : Physical Activity and Health

Parvin Farzanegi ¹ (Associate Professor, Sports Physiology Department, Sari Branch, Islamic Azad University, Sari, Iran)

Received: 2022-09-22 Accepted : 2022-12-05 Published : 2022-11-22

Keywords:

Abstract :

Endometriosis is inflammatory disease whose main feature is the abnormal growth of endometrial tissue including stroma and pseudo-endometrial glands outside the uterine cavity, in an abnormal manner.The purpose of this study was to investigate the effect of regular exercise along with vitamin B6 and omega-3 consumption on NF-KB gene expression in endometriosis model mice. In this experimental research, 40 Wistar rats were randomly divided into 8 groups ,control-healthy, endometriosis sham, endometriosis+exercise, endometriosis+B6, endometriosis+omega-3, endometriosis+exercise+B6, endometriosis+exercise+omega.Vitamin B6 was consumed at the rate of 60 mg/kg per body weight of each rat, and the amount of omega-3 consumption was daily and in the form of gavage with a dose of 2 mg/kg per body weight of each rat. The swimming training program was for 8 weeks and 5 days each week and for 30 minutes each day.The results showed that the level of NF-KB gene expression in the endometriosis group has increased significantly compared to the healthy control group. The endometriosis+exercise+B and endometriosis+exercise+omega groups had a significant decrease in the level of NF-KB gene expression compared to the endometriosis group.The endometriosis+exercise+B group had a significant decrease compared to the endometriosis+exercise and endometriosis+omega groups. In general, the results of the present research indicate that regulating and balancing NF-KB gene expression in the process of endometriosis can improve the level of this disease and swimming exercises and simultaneous consumption of omega-3 and vitamin B6 can restore the normal state of the NF gene. -KB will help.Keywords: endometriosis, omega-3, vitamin B6, NF-KB