The Effects of 8 Weeks of High and Moderate Intensity Interval Training on Irisin and Adipolin Levels in Type 2 Diabetic Male Rats
Subject Areas : Journal of Physical Activity and Hormones
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Keywords: Diabetes, Irisin, Adipolin and interval training,
Abstract :
Introduction: The purpose of this study was to compare the effects of high and moderate intensity interval training on Irisin and Adipolin levels in type 2 diabetic male rats.
Material & Methods: Thirty-two male Wistar rats were divided into two groups: healthy and diabetic, diabetic rats were randomly divided into three subgroups of diabetic control and two HIIT and MIIT groups; so that the present study was performed on four groups (8 per each group). The training was performed with 65-70% and 85-90% of the maximum oxygen consumption in MIIT and HIIT groups, respectively. Twenty-four hours after the last training session, the mice were removed by intraperitoneal injection of a combination of anaesthetic ketamine and xylazine. The levels of Irisin and adipolin were measured by ELISA method. Data were analysed by one-way ANOVA and Tukey's post hoc test.
Results: The results of the post hoc test indicated a significant increase in irisin and adipolin in the HIIT and MIIT groups compared to the control group (p = 0.001). There was no significant difference between HIIT and MIIT groups (p = 0.274).
Conclusion: HIIT and MIIT could lead to a significant increase in irisin and adipolin in diabetic rats.
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