Protective effect of nano magnesium oxide on renal ischemia/reperfusion injury on serum factors in male Wistar rats
Subject Areas : blood biochemistry & investigation of biomarkers
Marzieh
Minaei
1
(Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran)
اکرم
عیدی
2
(گروه زیست شناسی، واحد علوم و تحقیقات، دانشگاه آزاد اسلامی، تهران)
Pejman
Mortazavi
3
(Department of Pathology, Faculty of Specialized Veterinary Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran)
Ahmad
Asghari
4
(Department of Clinical Sciences, Faculty of Specialized Veterinary Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran)
Keywords: kidney, ischemia/reperfusion, Nano magnesium oxide, Rat,
Abstract :
Background & Aim: In recent years, nanotechnology has produced new forms of materials that are more effective than their predecessors. Magnesium plays a key role in many biological processes. The aim of this study was to investigate the effects of nano magnesium oxide (Nano-MgO) on renal ischemia/reperfusion (I/R) as a common complication of renal vascular surgery or renal transplantation in a male rat model. Materials & Methods: In this study, Induction of I/R injury was done through clamping left renal pedicle for 20 min. Animals were administrated with Nano-MgO (1.25, 2.5 and 5 mg/kg) for 30 days by gavage and then blood samples were collected and changes in serum albumin, total protein, urea and creatinine were examined and the data were statistically analyzed (p <0.05). Results: Our findings showed that Nano-MgO administration to renal I/R injury rats significantly attenuates serum creatinine and urea levels. Also, administration of Nano-MgO increased serum albumin and total protein levels. Conclusion: The Nano-MgO administration preserves renal function and As a potent vasodilator, Nano-MgO may have been able to reduce kidney damage following ischemia-reperfusion induction.
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