The effect of two training methods (continuous and periodic) and ginger supplementation on the balance of apoptosis and oxidation pathway in heart tissue of breast cancer model rats
Subject Areas :
Mohammad Hossein Bargahi
1
,
parvin farzanegi
2
,
Farzad Feli Kohikheili
3
1 - Department of Exercise Physiology, Sari Branch, Islamic Azad University, Sari, Iran
2 - Associate Professor, Exercise Physiology Department, Sari Branch, Islamic Azad University, Sari, Iran
3 - Assistant Professor, Islamic Azad University, Neka Branch, Neka, Iran
Keywords: Heart tissue, Continuous and intermittent exercise, breast cancer, Apoptosis, Ginger,
Abstract :
Introduction and Objective: Today, breast cancer is one of the most common malignant diseases in women and its incidence is increasing, the aim of the present research was the effect of continuous and intermittent training methods with ginger supplement on the balance of apoptosis and oxidation pathway in heart tissue of breast cancer model rats.Methodology: In this experimental research, 56 mice were randomly divided into 8 groups: 1) control, 2) cancer, 3) cancer-saline, 4) cancer-supplement, 5) cancer-periodic, 6) cancer-continuous, 7) cancer-periodic-supplement and 8) cancer-continuous-supplement group were placed. The continuous program of the first week with a speed of 15 m/min for a duration of five minutes on the treadmill, which increased the speed by 1-2 m/min every week and increased the running time by 1-2 minutes. Intermittent training includes six sets of 2.5 minutes, with four minutes of rest between each set. Results: The results showed that the induction of cancer increased the expression of BAX and MDA in the heart tissue of rats and significantly decreased the expression of BCL-2 and SOD, each of the interventions (continuous exercise, ginger and the combination of continuous and intermittent exercise with ginger supplement) The cardiac expression of BAX and MDA decreased and the expression of BCL-2 and SOD increased significantly.Conclusion: The results confirm the role of continuous and periodic exercise with ginger supplement in improving the apoptotic and oxidative indices of heart tissue in breast cancer mice, which may have a protective effect on heart tissue.
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