Study of Changes Kidney Tissue of White Albino NMRI Mice affected by the Gasoil
Subject Areas :
Nasim
Naeimi
1
(کارشناسی ارشد(هیات علمی)، گروه زیست شناسی، دانشکده علوم، دانشگاه سیستان و بلوچستان، زاهدان. ایران)
Zohreh
Fazlollahi
2
(کارشناسی ارشد فیزیولوژی جانوری،گروه زیست شناسی ،دانشکده علوم،دانشگاه رازی کرمانشاه ،کرمانشاه. ایران)
Hamid reza
Adeli
3
(دانشجوی دکتری زیست شناسی تکوینی ، دانشگاه علوم و تحقیقات تهران. ایران)
Kobra
Zare
4
(دکتری فیزیولوژی جانوری، دانشگاه علوم و تحقیقات ، تهران. ایران.)
Nima
Mehrabi
5
(دانشجوی زیست شناسی سلولی و مولکولی ،دانشگاه پیشوا ورامین،ورامین. ایران.)
Keywords: Kidney Parameters, Histology, gasoil, White Albino NMRI Mice,
Abstract :
Inroduction & ObjectiveGasoil is one of mostly-used oil products applied as diesel fuel, for instance, which, since it consists of aromatic compounds, is among the most important environmental pollutants. Considering its harmful effects on living organisms and human beings, the purpose of the present study was to investigate the effects of gasoil ingestion on kidney factors of white Albino NMRI mice.Materials and Methods:40 adult mice, with an average weight of 28 grams, were placed in four groups. Adult male mice were placed in two groups including a control group and a treatment group and adult female mice were divided into two groups of control and treatment. For 14 days, the treatment groups were fed once per day with 0.2cc of pure gasoil solution with a ratio of 6.6 mg/kg of the mice’s weightAfter weighing, anesthesia and macroscopic and microscopic studies of through the slides prepared, the desired parameters measured using the software motik. Then, the analyses were performed using SPSS V:19 software.ResultsIn the male and female extreatmentgroupscompared to thecontrol group in Variations in kidney tissue,indicated a significantrelationship(Pthe outercortex(except theinnercortex) kidney(30%,40%), increased thickness of the internal and externalmedulla(20%,21%). Reduced diameter of the proximal (43%) and distal tubule(30%), increased diameter of collecting tubule(60%,30%).Conclusion: Due to the increased use of gasoil and generalization of the results of the present research to human kidney tissue damage, this substance imposes irrecoverable damages on human health. Hence, necessary measures should be taken by authorities for replacing, reducing its effects and raising public awareness of the methods of dealing with its effects.
