Study Effects Of Hydroalcoholic Extract Of Medicago sativa in the Treatment Of Acetic Acid Induced Gastric Ulcer in Rats

Subject Areas :

Mahdi  Margani ¹ (دانشگاه آزاد اسلامی واحد کرج، دانشکده دامپزشکی، دانشیار گروه علوم درمانگاهی)
Hamed  Alizadeh ² (دانشگاه آزاد اسلامی، واحد زنجان، باشگاه پژوهشگران جوان و نخبگان، زنجان، ایران.)
Sina  Aghshahi ³ (دانشگاه آزاد اسلامی، واحد کرج، دانشکده دامپزشکی، کرج، ایران)

Received: 2015-03-09 Accepted : 2018-08-04 Published : 2014-07-23

Keywords: Seminiferous, Spermatogenesis, Ricinus communissexual hormones,

Abstract :

Inroduction and Objective:Peptic ulcer, from histologicalpointisknownasmucosalnecrosisfactor. The purpose of this study was to investigate the effect of Alfalfa hydroalcoholicvegetivearial organs extract on gastric ulcer induced by acetic acid in Rat.Material and Methods: In this experimental study, 60 wistar rats weighting approximately (200-250g) were randomly divided into 4 groups; control, sham(normal salin), experiment 1 (extract of dose 250 mg/kg body weight) and experiment 2 (extract of dose 500 mg/kg body weight). Rats were deprived of food and then underwent surgeryand gastric wasby injecting60% acetic acid after 4,7,10,14 days gavage, the rats' stomach out and then measuring the wound and fixed with 10% formalin, the passage of the tissue section was stained And the number of neutrophils, macrophages and fibroblasts were counted.Results:Results showed that the hydroalcoholic extract of Alfalfacaused a significant increase in gastric ulcer healing in experimental groups 1 and 2 (PConclusion:Alfalfahydroalcoholic vegetive arial organs extract is effective in the treatment of peptic ulcer induced by acetic acid