Blood coagulation effect of combined extract of Thymus vulgaris and Medicago sativa

Subject Areas : Medicinal and Herbal Plants

Zahra Sadat Mashkani ¹ (Department of Biology, Hakim Sabzevari University, Sabzevar, Iran)
Jafar Vatandoost ² (Department of Biology, Hakim Sabzevari University, Sabzevar, Iran)
Toktam Hajjar ³ (Department of Biology, Hakim Sabzevari University, Sabzevar, Iran)
Behnam Mahdavi ⁴ (Department of Chemistry, Hakim Sabzevari University, Iran)

Received: 2023-12-05 Accepted : 2024-03-17 Published : 2024-09-21

Keywords: Thymus vulgaris, Medicago sativa, Herbal medicine, Hemophilia,

Abstract :

Thymus vulgaris and Mediacgo sativa, are used as a traditional remedy in the treatment of bleeding disorders. Considering their probabilistic coagulation compounds, in an animal study, forty male mice were randomly divided into 5 groups (n = 8) as well as negative and positive control. Coagulation indices include bleeding time (BT), clotting time (CT), and the number of platelets (PLT) were examined on the 13th day of treatment. A significant reduction in the BT and CT tests, as well as a significant increase in PLT in the treated groups was observed. It is concluded that although the T. vulgaris and M. sativa extracts have a coagulation effect through primary homeostasis and a common pathway of secondary hemostasis, combined extracts are more effective than individual extracts. Moreover, phenolic and flavonoid compounds are the most affecting compounds that affect platelet number and aggregation.

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