Blood coagulation effect of combined extract of Thymus vulgaris and Medicago sativa
Subject Areas : Medicinal and Herbal PlantsZahra Sadat Mashkani 1 , Jafar Vatandoost 2 , Toktam Hajjar 3 , Behnam Mahdavi 4
1 - Department of Biology, Hakim Sabzevari University, Sabzevar, Iran
2 - Department of Biology, Hakim Sabzevari University, Sabzevar, Iran
3 - Department of Biology, Hakim Sabzevari University, Sabzevar, Iran
4 - Department of Chemistry, Hakim Sabzevari University, Iran
Keywords: Thymus vulgaris, Medicago sativa, Herbal medicine, Hemophilia,
Abstract :
Thymus vulgaris and Mediacgo sativa, are used as a traditional remedy in the treatment of bleeding disorders. Considering their probabilistic coagulation compounds, in an animal study, forty male mice were randomly divided into 5 groups (n = 8) as well as negative and positive control. Coagulation indices include bleeding time (BT), clotting time (CT), and the number of platelets (PLT) were examined on the 13th day of treatment. A significant reduction in the BT and CT tests, as well as a significant increase in PLT in the treated groups was observed. It is concluded that although the T. vulgaris and M. sativa extracts have a coagulation effect through primary homeostasis and a common pathway of secondary hemostasis, combined extracts are more effective than individual extracts. Moreover, phenolic and flavonoid compounds are the most affecting compounds that affect platelet number and aggregation.
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