Triterpenic and acyl glycosides from the leaves of Centella asiatica (L.) Urban

Subject Areas : Pharmacognosy

Iram Rais ¹ , Mohammad Ali ²

1 - Department of Biochemistry, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi-110 062, India
2 - Phytochemistry Research Laboratory, School of Pharmaceutical Sciences and Research, Jamia Hamdard, New Delhi-110 062, India

Received: 2017-09-24 Accepted : 2018-02-07 Published : 2018-03-01

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References:

Aizad, S., Mohd Khairiri, N., Yahaya, B.H., Zubairi, S.I., 2017. A novel anti-proliferative activity (EC₅₀) of pegaga (Centella asiatica) extract through in vitro 3-D culture microenvironment. J. Teknol. 79(2), 1-10.

Ali, M., 2001. Techniques in Terpenoid Identification. Birla Publications, New Delhi, India.

Azis, H.A., Taher, M., Ahmed, A.S., Sulaiman, W.M.A.W., Susanti, D., Chowdhury, S.R., Zakaria, Z.A., 2017. In vitro and In vivo wound healing studies of methanolic fraction of Centella asiatica extract. S. Afr. J. Bot. 108, 163-174.

Aziz, Z.A., Davey. M.R., Power, J.B., Anthony, P., Smith. R.M., Lowe, K.C., 2007. Production of asiaticoside and madecassoside in Centella asiatica in vitro and in vivo. Biol. Plant. 51(1), 34-42.

Brinkhaus, B.，Lindner, M.，Schuppan, D., 2000. Chemical，pharmacological and clinical profile of the East Asian medical plant Centella asiatica. Phytomedicine 7(5), 427-448.

Chong, N.J., Aziz, Z., 2011. A systematic review on the chemical constituents of Centella asiatica. Res. J. Pharm. Biol. Chem. Sci. 2(3), 445-459.

Chopra, R.N., Nayar. S.L., Chopra. I.C., 1986. Glossary of Indian Medicinal Plants (Including the Supplement) New Delhi. Council of Scientific and Industrial Research, New Delhi, India.

Fitrianda, E., Sukandar, E.Y., Elfahmi, Adnyana, I.K., 2017. Antidiabetic activity of extract, fractions, and asiaticoside compound isolated from Centella asiatica Linn. Leaves in alloxan-induced diabetic mice. Asian J. Pharm. Clin. Res. 10(10), 268-272.

Gohil, K.J., Patel, J.A., Gajjar, A.K., 2010. Pharmacological review on Centella asiatica: A potential herbal cure-all. Indian J. Pharm. Sci. 72(5), 546-556.

Hashim, P., Sidek, H., Helan, M.H.M., Sabery, A., Palanisamy. U.D., Ilham, M., 2011. Triterpene composition and bioactivities of Centella asiatica. Molecules 16, 1310-1322.

Idris, F.N., Nadzir, M.M., 2017. Antimicrobial activity of Centella asiatica on Aspergillus niger and Bacillus subtilis, in: Klemes, J.J., Liew, P.Y., Ho, W.S., Lim, J.S. (Eds.), Chemical Engineering Transactions. Italian Association of Chemical Engineering - AIDIC, pp. 1381-1386.

James, J.T., Dubery, I.A., 2009. Pentacyclic triterpenoids from the medicinal herb, Centella asiatica (L.) Urban. Molecules 14, 3922-3941.

Jiang, Z.Y.，Zhang, X.M.，Zhou, J., 2005. New triterpenoid glycosides from Centella asiatica．Helv. Chim. Acta. 88(2), 297-303.

Khan, M.A., Ali, M., Alam, P., 2010. Phytochemical investigation of the fruit peels of Citrus reticulata Blanco, Nat. Prod. Res. 24(7), 610-620.

Kuroda, M., Mimaki, Y., Harada, H., Sakagami, H., Sashida, Y., 2001. Five new triterpene glycosides from Centella asiatica. Nat. Med. 55(3), 134-138.

Machado, R.R.P., Dutra, R.C., Pittella, F., Raposo, N.R.B., Lesche, B., Duarte, R.S., Soares, G.L.G., Kaplan, M.A.C., 2015. Screening antimycobacterial activity of Baccharis dracunculifolia, Centella asiatica, Lantana camara and Pterodon emarginatus. Rev. Bras. Plantas Med. 17(4), 891-899.

Machado, R.R.P., Dutra, R.C., Pittella, F., Raposo, N.R.B., Lesche, B., Duarte, R.S., Soares, G.L.G., Kaplan, M.A.C., 2015. Screening antimycobacterial activity of Baccharis dracunculifolia, Centella asiatica, Lantana camara and Pterodon emarginatus. Rev. Bras. Plantas Med. 17(4), 891-899.

Mahato, S.B., Kundu, A.P., 1994. ¹³C NMR spectra of pentacyclic compounds-A complication and some salient features. Phytochemistry 37, 1517-1575.

Matsuda, H.，Morikawa, T.，Ueda, H., Yoshikawa M., 2001a. Medicinal foodstuffs．XXVI．Inhibitors of aldose reductase and new triterpene and its oligoglycoside，centellasapogenol A and centellasaponin A，from Centella asiatica （Gotu Kola). Heterocycles 55(8), 1499-1504.

Matsuda, H.， Morikawa, T.，Ueda, H.，Yoshikawa, M., 2001b. Medicinal foodstuffs. XXVII．Saponin constituents of gotu kola (2): structures of new ursane and oleanane type triterpene oligoglycosides，centellasaponins B，C,and D from Centella asiatica cultivated in Sri Lanka．Chem. Pharm. Bull. 49(10), 1368-1371.

Nataraj, J., Manivasagam, T., Justin Thenmozhi, A., Essa, M.M., 2017. Neurotrophic effect of asiatic acid, a triterpene of Centella asiatica against chronic 1-methyl 4-phenyl 1, 2, 3, 6-tetrahydropyridine hydrochloride/probenecid mouse model of Parkinson’s disease: The role of MAPK, PI3K-Akt-GSK3β and mTOR signalling pathways. Neurochem. Res. 42(5), 1354-1365.

Oyedeji, O.A.，Afolayan, A.J., 2005. Chemical composition and antibacterial activity of the essential oil of Centella asiatica growing in South Africa. PharmBiol. 43(3), 249-252.

Panathula, C.S., Mahadev, M.D., Naidu, C.V., 2014. Phytochemical investigation and in vitro antimicrobial activity of Centella asiatica (L.) Urban. A potent antijaundice medicinal plant. Int. J. Phytomedicine 6(2), 195-200.

Park, J.H., Choi, J.Y., Son, D.J., Park, E.K., Song, M.J., Hellström, M., Hong, J.T., 2017. Anti-inflammatory effect of titrated extract of Centella asiatica in phthalic anhydride-induced allergic dermatitis animal model. Int. J. Mol. Sci. 18(4).

Qin, L.P.，Ding, R.X.，Zhang, W.D., 1998. Essential oil from Centella asiatica and its antidepressant activity. Di Er Jun Yi Da Xue Xue Bao. 19(2), 186-187.

Quattrocchi, U., 2012. CRC World Dictionary of Medicinal and Poisonous Plants: Common Names, Scientific Names, Eponyms, Synonyms and Etymology. CRC Press, Boca Raton, Florida.

Shukla, Y.N.，Srivastava, R.，Tripathi, A.K.，Prajapati V., 2000. Characterization of an ursane triterpenoid from Centella asiatica with growth inhibitory activity against Spilarctia obliqua．Pharm. Biol. 38(4), 262-267.

Siddiqui, B.S., Aslam, H., Ali, S.T., Khan, S., Begum, S., 2007. Chemical constituents of Centella asiatica. J. Asian Nat. Prod. Res. 9(4), 407-414.

Singh, S., Gautam, A., Sharma, A., Batra, A., 2010. Centella asiatica (L.): A plant with immense medicinal potential but threatened. Int. J. Pharm. Sci. Rev. Res. 4(2), 9-17.

Sultan, R.A., Mahmood, S.B.Z., Azhar, I., Ahmed, S.W., Mahmood, Z.A., 2014. Biological activities assessment of Centella asiatica (Linn.). J. Herbs Spices Med. Plants 20(3), 319-327.

Wijeweera, P., Arnason, J.T., Koszycki, D., Merali, Z., 2006. Evaluation of anxiolytic properties of Gotukola-(Centella asiatica) extracts and asiaticoside in rat behavioral models. Phytomedicine, 13(9-10), 668-676.

Zainol, M.K.，Abd-Hamid, A.，Yusof, S.，Muse, R., 2003. Antioxidative activity and total phenolic compounds of leaf，root and petiole of four accessions of Centella asiatica （L）Urban．Food Chem. 81(4), 575-581.

Zheng, C.J., Qin, L.P., 2007. Chemical components of Centella asiatica and their bioactivities. J. Chin. Integr. Med. 5(3), 348-351.

Zheng, H.M., Choi, M.J., Kim, J.M., Cha, K.H., Lee, K.W., Park, Y.H., Hong, S.S., Lee, D.H., 2016. Centella asiatica leaf extract protects against indomethacin-induced gastric mucosal injury in rats. J. Med. Food 19(1), 38-46.