The predominant microbiota of the human intestine is an important risk factor for colon cancer
Mohammad Khalilollahi
1
(Department of Microbiology, Islamic Azad University, North Tehran Branch, Tehran, Iran)
Shahla mohammad Ganji
2
(Departments of Molecular Medicine, National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran)
fatemeh ashrafi
3
(Department of Genetics, Faculity of science, North Tehran Branch, Islamic Azad University, Tehran, Iran)
Keywords: microbiota, pks, Colon cancer, Risk Factor, toxin,
Abstract :
The digestive system consists of esophagus, stomach, small intestine and large intestine. The large intestine starts from the end of the small intestine and ends at the anus. The anus is the opening of the large intestine that leads to the outside of the body. Colon is another name for large intestine. Cancer occurs when malignant or cancerous cells form in the colon. Colon cancer is also known as colon cancer, colon and rectal cancer or colorectal cancer. Colorectal cancer or CRC is one of the most common malignant human tumors. Environmental and epigenetic factors are the most important causes of this disease. Among the risk factors associated with this complex disease, infection by various microorganisms can be mentioned. Microorganisms such as bacteria, parasites, fungi, viruses, molds and yeasts among which microbiota play a more important role. In this article, with an overview of the dominant microbiota in the human intestine, its role as an important risk factor in colon cancer will be investigated. Factors such as the results of disruption of the regulation and structure of microbiota, bacterial metabolites or inflammatory pathways and facilitation of the colon cancer pathway will be discussed.
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