Review on Laboratory tests for Diagnosis of Hepatitis C Virus Infection

Subject Areas : microbiology

Abbas  Morovvati ¹ (management and teacher)
somayeh  dehghani sanij ² (Aria azma laboratory managment)
Ashkan  Dirbaziyan ³ (Lecture, Phd students in Microbiology, Department of microbiology, Qom Branch, Islamic Azad University, Qom, Iran.)
homa  Azadegan ⁴ (student, MS in Microbiology, Department of microbiology, Qom Branch, Islamic Azad University, Qom, Iran.)
shima  Aghaei ⁵ (student, MS in Microbiology, Department of microbiology, Qom Branch, Islamic Azad University, Qom, Iran.)
hasan  vahidi emami ⁶ (Lecture, MsC in Microbiology, Department of microbiology, Qom Branch, Islamic Azad University, Qom, Iran.)

Received: 2018-12-01 Accepted : 2019-08-04 Published : 2019-08-23

Keywords: hepatitis C virus, molecular diagnostics, hepatocellular carcinoma, hepatitis,

Abstract :

Abstract Hepatitis C virus (HCV) infection is associated with chronic hepatitis, cirrhosis, and hepatocellular carcinoma. This review summarizes the pathogenesis and significance of serological and molecular-based assays and new methods in the diagnosis and management of HCV infection after reading this article, readers should be able to describe laboratory tests used in the diagnosis and management of HCV infection. They should also be able to describe the general principles for selecting the most appropriate laboratory test for diagnosis, therapeutic decision making, and assessment of virologic response to therapy. New methods for diagnosis of HCV virus infection could help for HCV detection and virus Genotypes in patient. Molecular methods are very sensitive and specific for RNA diagnosis and uses of this test for HCV genotypes Because HCV genotypes different response to druges.HCV genotypes detection could help for follow up treatment by interferon of patient. Keywords: hepatitis C virus, hepatitis, hepatocellular carcinoma, molecular diagnostics