The effect of turmeric (Curcuma longa) powder on liver function, serum levels of pro-inflammatory cytokines, and antioxidant status biomarkers in male Japanese quails fed a cadmium-contaminated diet

Subject Areas : Journal of Comparative Pathobiology

, O Karimi ¹ , , M.R Mofdi ² , , M. Bitaraf Sani ³

1 - Department of Animal Viral Diseases Research, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization, Karaj, Iran
2 - Department of Animal Science Research, Yazd Agricultural and Natural Resources Research and Education Center, Agricultural Research, Education and Extension Organization, Yazd, Iran
3 - Department of Animal Science Research, Yazd Agricultural and Natural Resources Research and Education Center, Agricultural Research, Education and Extension Organization, Yazd, Iran

Received: 2021-11-03 Accepted : 2021-11-03 Published : 2021-05-22

Keywords: Cadmium, Turmeric powder, Japanese quail, oxidative stress, inflammation,

Abstract :

Environmental pollution by cadmium (Cd) is increasing. The entry of this heavy toxic metal into the food chain is a serious danger to human and animal populations. This study aims to evaluate the effect of turmeric (Curcuma longa) powder (TP) containing 2.96% of total curcuminoides (TCM) in modulating the adverse impacts of Cd in Japanese quail. 180 22-day-old male Japanese quails were randomly divided into six groups for 23 days and fed a basal diet (BD) supplemented with 3 gr/kg TP (containing 88.18 mg of TCM), 5 mg/kg TP (containing 148 mg of TCM), 100 mg/kg Cd, 3 mg/kg TP plus 100 mg/kg Cd, and 5 gr/kg TP and 100 mg/kg Cd. The addition of TP to the Cd-contaminated diet reduced serum levels of pro-inflammatory cytokines TNF-αand IL-6, improved total antioxidant capacity, increased SOD and CAT activity, as well as decreasing MDA concentration. The TP supplementation significantly (p<0.05) reduced the harmful effects of Cd on body weight loss, relative liver weight gain, and total protein concentration, besides increasing serum levels of ALT, AST, and ALP enzymes. The findings of this study suggest that TP may reduce the toxic effects of Cd in Japanese quail by improving antioxidant status and reducing the activity of pro-inflammatory cytokines. The addition of 5 g/kg TP to the Cd-contaminated diet results in more antioxidant and anti-inflammatory properties than 3 g/kg TP.

References:

1. Saleemi MK, Tahir MW, Abbas RZ, Akhtar M, Ali A, Javed MT, et al. Amelioration of toxicopathological effects of cadmium with silymarin and milk thistle in male Japanese quail (Coturnix japonica). Environmental science and pollution research. 2019;26(21):21371-80.

2. Rahman Z, Singh VP. The relative impact of toxic heavy metals (THMs)(arsenic (As), cadmium (Cd), chromium (Cr)(VI), mercury (Hg), and lead (Pb)) on the total environment: an overview. Environmental monitoring and assessment. 2019;191(7):1-21.


3. Abou-Kassem D, Mahrose KM, Alagawany M. The role of vitamin E or clay in growing Japanese quail fed diets polluted by cadmium at various levels. animal. 2016;10(3):508-19.


4. Ge J, Zhang C, Sun Y-C, Zhang Q, Lv M-W, Guo K, et al. Cadmium exposure triggers mitochondrial dysfunction and oxidative stress in chicken (Gallus gallus) kidney via mitochondrial UPR inhibition and Nrf2-mediated antioxidant defense activation. Science of The Total Environment. 2019;689:1160-71.


5. García-Niño WR, Pedraza-Chaverrí J. Protective effect of curcumin against heavy metals-induced liver damage. Food and Chemical Toxicology. 2014;69:182-201.


6. Butt SL, Saleemi MK, Khan MZ, Khan A, Farooq M, Khatoon A, et al. Cadmium toxicity in female Japanese quail (Coturnix japonica) and its diminution with silymarin. Pakistan Veterinary Journal. 2018;38(3):249-55.


7. Hossein-Khannazer N, Azizi G, Eslami S, Alhassan Mohammed H, Fayyaz F, Hosseinzadeh R, et al. The effects of cadmium exposure in the induction of inflammation. Immunopharmacology and immunotoxicology. 2020;42(1):1-8.


8. Cao H, Gao F, Xia B, Zhang M, Liao Y, Yang Z, et al. Alterations in trace element levels and mRNA expression of Hsps and inflammatory cytokines in livers of duck exposed to molybdenum or/and cadmium. Ecotoxicology and environmental safety. 2016;125:93-101.


9. Tang K-K, Li H-Q, Qu K-C, Fan R-F. Selenium alleviates cadmium-induced inflammation and meat quality degradation via antioxidant and anti-inflammation in chicken breast muscles. Environmental Science and Pollution Research. 2019;26(23):23453-9.


10. Darwish WS, Atia AS, Khedr MH, Eldin WFS. Metal contamination in quail meat: residues, sources, molecular biomarkers, and human health risk assessment. Environmental Science and Pollution Research. 2018;25(20):20106-15.


11. Tahir MW, Saleemi MK, Khan A, Yousaf M, Butt SL, Siriwong W, et al. Hematobiochemical effects of cadmium intoxication in male Japanese quail (Coturnix japonica) and its amelioration with silymarin and milk thistle. Toxin reviews. 2017;36(3):187-93.


12. Suljević D, Islamagić E, Čorbić A, Fočak M, Filipić F. Chronic cadmium exposure in Japanese quails perturbs serum biochemical parameters and enzyme activity. Drug and chemical toxicology. 2020;43(1):37-42.


13. Karimi O, Hesaraki S, Mortazavi SP. Histological and functional alteration in the liver and kidney and the response of antioxidants in Japanese quail exposed to dietary cadmium. Iranian Journal of Toxicology. 2017;11(3):19-26.


14. Li J-L, Jiang C-Y, Li S, Xu S-W. Cadmium induced hepatotoxicity in chickens (Gallus domesticus) and ameliorative effect by selenium. Ecotoxicology and environmental safety. 2013;96:103-9.


15. Patel SS, Acharya A, Ray R, Agrawal R, Raghuwanshi R, Jain P. Cellular and molecular mechanisms of curcumin in prevention and treatment of disease. Critical reviews in food science and nutrition. 2020;60(6):887-939.


16. Mohajeri M, Rezaee M, Sahebkar A. Cadmium‐induced toxicity is rescued by curcumin: a review. Biofactors. 2017;43(5):645-61.


17. Karimi O, Mofidi MR, Saeidabadi MS. Impact of Turmeric Curcuma longa on the Body Weight and Liver Function of Japanese Quails Exposed to Dietary Aflatoxins. Iranian Journal of Toxicology. 2020;14(2):115-22.


18. Moniruzzaman M, Min T. Curcumin, curcumin nanoparticles and curcumin nanospheres: A review on their pharmacodynamics based on monogastric farm animal, poultry and fish nutrition. Pharmaceutics. 2020;12(5):447.


19. Additives EPo, Feed PoSuiA, Bampidis V, Azimonti G, Bastos MdL, Christensen H, et al. Safety and efficacy of turmeric extract, turmeric oil, turmeric oleoresin and turmeric tincture from Curcuma longa L. rhizome when used as sensory additives in feed for all animal species. EFSA Journal. 2020;18(6):e06146.


20. Abd El‐Wahab A, Mahmoud RE, Ahmed MF, Salama MF. Effect of dietary supplementation of calcium butyrate on growth performance, carcass traits, intestinal health and pro‐inflammatory cytokines in Japanese quails. Journal of Animal Physiology and Animal Nutrition. 2019;103(6):1768-75.


21. Liu L-l, Li C-m, Zhang Z-w, Zhang J-l, Yao H-d, Xu S-w. Protective effects of selenium on cadmium-induced brain damage in chickens. Biological trace element research. 2014;158(2):176-85.


22. Unsal V, Dalkıran T, Çiçek M, Kölükçü E. The role of natural antioxidants against reactive oxygen species produced by cadmium toxicity: a review. Advanced pharmaceutical bulletin. 2020;10(2):184.


23. Erdogan Z, Erdogan S, Celik S, Unlu A. Effects of ascorbic acid on cadmium-induced oxidative stress and performance of broilers. Biological Trace Element Research. 2005;104(1):19-31.


24. Genchi G, Sinicropi MS, Lauria G, Carocci A, Catalano A. The effects of cadmium toxicity. International journal of environmental research and public health. 2020;17(11):3782.


25. Wang Y, Liu J, Chen R, Qi M, Tao D, Xu S. The Antagonistic Effects of Selenium Yeast (SeY) on Cadmium-Induced Inflammatory Factors and the Heat Shock Protein Expression Levels in Chicken Livers. Biol Trace Elem Res. 2020;198(1):260-8.


26. Cai J, Zhang Y, Yang J, Liu Q, Zhao R, Hamid S, et al. Antagonistic effects of selenium against necroptosis injury via adiponectin-necrotic pathway induced by cadmium in heart of chicken. RSC advances. 2017;7(70):44438-46.


27. Zhang R, Liu Y, Xing L, Zhao N, Zheng Q, Li J, et al. The protective role of selenium against cadmium-induced hepatotoxicity in laying hens: expression of Hsps and inflammation-related genes and modulation of elements homeostasis. Ecotoxicology and environmental safety. 2018;159:205-12.


28. Liu C, Zhu Y, Lu Z, Guo W, Tumen B, He Y, et al. Cadmium Induces Acute Liver Injury by Inhibiting Nrf2 and the Role of NF-κB, NLRP3, and MAPKs Signaling Pathway. International journal of environmental research and public health. 2020;17(1):138.


29. Wang H, Zhang R, Song Y, Li T, Ge M. Protective effect of ganoderma triterpenoids on cadmium-induced testicular toxicity in chickens. Biological trace element research. 2019;187(1):281-90.


30. Alghasham A, Salem TA, Meki A-RM. Effect of cadmium-polluted water on plasma levels of tumor necrosis factor-α, interleukin-6 and oxidative status biomarkers in rats: protective effect of curcumin. Food Chem Toxicol. 2013;59:160-4.


31. KUMAŞ M, EŞREFOĞLU M, Bayindir N, Iraz M, AYHAN S, Meydan S. Protective Effects of Curcumin on Cadmium-Induced Renal Injury in Young and Aged Rats. Histopathology. 2016;2013:231.


32. Attia AM, Ibrahim FA, Abd EL-Latif NA, Aziz SW. Antioxidant effects of curcumin against cadmium chloride-induced oxidative stress in the blood of rats. Journal of Pharmacognosy and Phytotherapy. 2014;6(3):33-40.


33. Eybl V, Kotyzová D, Bludovská M. The effect of curcumin on cadmium-induced oxidative damage and trace elements level in the liver of rats and mice. Toxicology Letters. 2004;151(1):79-85.


34. Akinyemi AJ, Adeniyi PA. Effect of essential oils from ginger (Zingiber officinale) and turmeric (Curcuma longa) rhizomes on some inflammatory biomarkers in cadmium induced neurotoxicity in rats. Journal of toxicology. 2018;2018.


35. Lee M, Lin W, Lee T. Potential crosstalk of oxidative stress and immune response in poultry through phytochemicals—A review. Asian-Australasian journal of animal sciences. 2019;32(3):309-319.


36. Ahmad RS, Hussain MB, Sultan MT, Arshad MS, Waheed M, Shariati MA, et al. Biochemistry, safety, pharmacological activities, and clinical applications of turmeric: A mechanistic review. Evidence-based complementary and alternative medicine. 2020, https://doi.org/10.1155/2020/7656919.