Evaluation of Serological and Pathological Changes after Partial and Complete Nephrectomy as Uni and Bilateral in Dog

Subject Areas : Journal of Comparative Pathobiology

غلامرضا عابدی ¹ , رحیم علیزاده ² , احمد اصغری ³ , علی چراغ زاده ⁴ , محمد خوانساری ⁵

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Received: 2011-06-27 Accepted : 2011-12-02 Published : 2012-02-20

Keywords: Nephrectomy, Vitamin D, Dog,

Abstract :

In many renal diseases, we have to do nephrectomy including renal cysts, hydronephrosis,polycystic kidney, etc. Nephrectomy can cause severe side effects. In this study, the effect ofnephrectomy on one of the important functions of kidney, the production of active vitamin D (1,25-dihydroxycholecalciferol) from inactive vitamin D, has been studied. In this study 15 mixedbreed healthy female dogs were divided into 3 group, including group 1 which underwent leftpartial nephrectomy, group 2 which underwent left total nephrectomy and group 3 whichunderwent left total nephrectomy and right partial nephrectomy. Blood samples were collected aday before surgery, on day of surgery and 45 days after surgery. Histopathology was done onsurgery day and 45 days after it. The results indicated that there was hypertrophy in theremained kidney 45 days after surgery. Also, in group 3 calcium was lower and urea, creatinineand phosphorus were higher than the normal range. However, in group 1 and 2 they were in thenormal range. The amount of vitamin D in group 3 showed significantly lower mean. Based onthe results, it is recommended that in all three groups active vitamin D and calcium are used asexogenous, although vitamin D wasn’t in the normal range only in group 3.