Anaesthetic effect of glutamate receptors blockers with/or without Alprazolam given by different routes and doses in animal model

Subject Areas : Journal of Comparative Pathobiology

ایلیاد عیسی بیگلو ¹ (ندارد)
احمد اصغری ² (ندارد)

Received: 2011-11-06 Accepted : 2012-05-31 Published : 2012-05-21

Keywords: Ketamine, Alprazolam, Anaesthesia, oral spray, Cat,

Abstract :

Ketamine one of the more important and clinical blocker of brain stimulatory neurotransmitter(glutamate) receptors is a suitable injectable anesthetic in human and animal that has a lowintestinal absorption rate. It's bioavailability in human with oral administration is %207 andwith rectal administration in cat is %43.56.1 .this drug has some side effects such ashypertension , histamine releasing effects, hallucination, hyper salivation (specially with oraladministration) and etc. Alprazolam is a mild acting benzodiazepine that can pass trough bloodbrainbarrier and causes CNS suppression. Then it seems that co administration of Alprazolamand ketamine cause more effective & deep CNS depression effects.The aim of this study was evaluation of ketamine and Alprazolam CNS suppression effects inthe manner of single and together in cat. Ten free roaming male & mature cats received drugs[ketamine (20, 40, 80mg/kg) & Alprazolam (5, 10, 15mg/kg)] first in mixture of milk (40ml) ormeat (30g) or sublingual spray rout. In 2nd stage they received concomitant doses ofAlprazolam & ketamine by the method mentioned above. Each animal was observed continuallyby educated observer for CNS depression as graded on the behavioral scales.Almost all of the animals rejected receiving drugs in mixture of milk and meat. So sublingualspray rout used for oral administration of drugs. Alprazolam & ketamine showed dosedependent effects in different administered doses. Concomitant use of Alprazolam withketamine improved depth and duration of ketamine's CNS depression effects. So results of thisstudy showed this fact that administration of ketamine & Alprazolam in mixture of milk & meatis not a suitable method in cats. Also Alprazolam in mentioned doses caused a weak suppressionof CNS. But a strong and long time CNS depression is achieved when ketamine sprayed inmouth (as sublingual form). These Symptoms are considered significant in co administration ofthese two drugs