Metal-free radical decarboxylation: an efficient approach for the direct synthesis of aryl-alkyl thioethers from carboxylic acids

Subject Areas : Others

Maral Salehi ¹ , Najmeh Nowrouzi ² , Mohammad Abbasi ³

1 - Chemistry Department, Faculty of Nano and Bio sciences and Technology, Persian Gulf University, Bushehr 75169, Iran.
2 - Chemistry Department, Faculty of Nano and Bio sciences and Technology, Persian Gulf University, Bushehr 75169, Iran.
3 - Chemistry Department, Faculty of Nano and Bio sciences and Technology, Persian Gulf University, Bushehr 75169, Iran.

Received: 2025-06-02 Accepted : 2025-06-11 Published : 2025-07-16

Keywords: Thioether, Carboxylic acid, Morpholine, Radical decarboxylation, Metal-free.,

Abstract :

In this study, a direct and metal-free method for the synthesis of thioethers from carboxylic acids and diaryl disulfides is introduced. The reaction is carried out in the presence of morpholine and base in dimethylformamide solvent and by a radical mechanism involving decarboxylation. This process offers a new route to the preparation of aryl-alkyl thioethers with high yield, tolerance of diverse functional groups, and without the need for thiol or metal catalysts.

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