Precise Prognosis of Hypercholesterolemia and Acute Kidney Diseases by Photonic Crystal Biosensor
Subject Areas : Journal of Optoelectronical Nanostructures
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Keywords: Acute kidney injury, Biosensor, Cholesterol, Creatinine, Photonic crystal,
Abstract :
In this research, a two-dimensional photonic crystal based hexagonal shaped system is proposed. The presented device is made of 35*42 silicon rods (which are placed in the air medium). Basic functionality processes of the proposed biosensor were studied through photonic bandgap (PBG) and filed distribution diagrams. PBG and field spectra were obtained through plane wave expansion (PWE) and finite-difference-time-domain (FDTD) numerical methods, respectively. The designed system is considered for diagnosis of cholesterol and creatinine concentrations in blood samples (these biological elements are introduced through their refractive indices). At specific wavelengths (placed in TE PBG region), light wave could be transferred along the waveguide and would reach outputs 1 or 2. Output1 can be applied for diagnosis of cholesterol concentrations in blood with quality factor (Q): (55.2 – 66.4), sensitivity (S): 1204.7nm/RIU, detection limit (DL): (0.0021–0.0031) RIU and figure of merit (FOM): (48.18–54.6) RIU-1. Output2 would be considered for detection of creatinine in blood with quality factor (Q): (175.7–195.5), sensitivity (S): 1957.3nm/RIU, detection limit (DL): (4.8e-4 –5.2e-4) RIU and figure of merit (FOM): (184.8–205.9) RIU-1. Considering obtained results, proposed device (biosensor) would aid physicians in prognosis of hypercholesterolemia (which can cause heart diseases and strokes) and acute kidney injuries.
[1] F. Parandin, A. Sheykhian, Design and simulation of a 2 × 1 All-Optical multiplexer based on photonic crystals. Optics & Laser Technology. 151 (2022) 108021.
[2] E. Rafiee, F. Emami, Design of a Novel All-Optical Ring Shaped Demultiplexer based on Two-Dimensional Photonic Crystals. Optik. 140 (2017) 873-877.
[3] F. Parandin, High contrast ratio all-optical 4 × 2 encoder based on two-dimensional photonic crystals. Opt. Laser Technol. 113 (2019) 447–452.
[4] E. Rafiee, et al., Design of a Novel Nano Plasmonic-Dielectric Photonic Crystal Power Splitter Suitable for Photonic Integrated Circuits. Optik. 172 (2018) 234-240
[5] F. Parandin, R. Kamarian, M. Jomour, A novel design of all optical half-subtractor using a square lattice photonic crystals. Opt Quant Electron. 53 (2021) 114.
[6] F. Parandin, et al., Design of 2D photonic crystal biosensor to detect blood Components, Opt Quant Electron. 54 (2022) 618.
[7] V. Zayets, at al., Fabrication technique for low-loss plasmonic waveguides incorporating both “plasmonic-friendly” and “plasmonic-unfriendly” metals, Photonics Nanostructures. 57 (2023) 101196.
[8] A. Ahmadianyazdi, et al., Glucose measurement via Raman spectroscopy of graphene: Principles and operation, Nano Res. 15, 8697–8704 (2022).
[9] G. Palai, et al., Optical MUX/DEMUX using 3D photonic crystal structure: A future application of silicon photonics. Optik 128 (2017) 224–227.
[10] A. Vahdati, F. Parandin, Antenna patch design using a photonic crystal substrate at a frequency of 1.6 THz, Wireless Pers. Commun. 109 (2019) 2213–2219.
[11] F. Parandin, M. Moayed, Designing and simulation of 3-input majority gate based on two-dimensional photonic crystals, Optik 216 (2020) 164930, https://doi.org/ 10.1016/j.ijleo.2020.164930.
[12] F. Parandin, Ultra-compact terahertz all-optical logic comparator on GaAs photonic crystal platform, Opt. Laser Technol. 144 (2021) 107399, https://doi.org/ 10.1016/j.optlastec.2021.107399
[13] F. Parandin, F. Heidari, Z. Rahimi, S. Olyaee, Two-dimensional photonic crystal Biosensors: A review, Opt. Laser Technol. 144 (2021) 107397, https://doi.org/ 10.1016/j.optlastec.2021.107397.
[14] A. Askarian, Design and analysis of all optical 2 × 4 decoder based on kerr effect and beams interference procedure, Opt Quant Electron 53 (2021) 291.
[15] E. Rafiee, et al., Hypercholesterolemia diagnosis by a biosensor based on photonic crystal PANDA structure. Opt Rev. 31(2024) 87–93.
[16] F. Parandin, et al., A comprehensive review of blood component detection utilizing
One-Dimensional, Two-Dimensional, and photonic crystal fiber biosensors, Results Opt.. 16 (2024) 100671.
[17] N. Tasnim, et al., Highly sensitive photonic crystal fiber based surface plasmon resonance biosensor for detection of wide range of organic solutions, Sens. Bio-Sens. Res. 43 (2024) 100623.
[18] A. Panda, et al., Performance analysis of graphene-based surface plasmon resonance biosensor for blood glucose and gas detection, Appl. Phys. A. 126 (2020). DOI:10.1007/s00339-020-3328-8.
[19] A. H. Aly, D. Mohamed, M. A. Mohaseb, N. S. Abd El-Gawaad, Y. Trabelsi, Biophotonic sensor for the detection of creatinine concentration in blood serum based on 1D photonic crystal, RSC Adv. 10 (2020) 31765. https://doi.org/10.1039/D0RA05448H.
[20] D. Dash and J. Saini, Hyperbolic Graded Index Biophotonic Cholesterol Sensor with Improved Sensitivity, Prog. Electromagn. Res.M. 116 (2023) 165-176.
[21] M. Rahman, et al., Photonic crystal fiber based terahertz sensor for cholesterol detection in human blood and liquid foodstuffs, Sens. Bio-Sens. Res. 29 (2020) 100356.
[22] A. Kumar, et al., Ultrahigh sensitive graphene oxide/conducting polymer composite based biosensor for cholesterol and bilirubin detection, Biosens. Bioelectron: X. 13 (2023) 100290.
[23] R. Negahdari, et al., Sensitive MIM plasmonic biosensors for detection of hemoglobin, creatinine and cholesterol concentrations, Diam. Relat. Mater.136 (2023) 110029.
[24] Y. F. Gao, et al., Design of novel power splitters by directional coupling between photonic crystal waveguides, Optoelectron. Lett. 6 (2010) 417–420. https://doi.org/10.1007/s11801-010-0017-4.
[25] s. Olyaee, et al., A.: Two-curve-shaped biosensor using photonic crystal nano-ring resonators., JNS. 4 (2014) 303–308.
[26] H. Ma, Cholesterol and Human Health, Nat. Sci. 2 (4), (2004) 17-21.
[27] H. T. Chorsi, et al.: Tunable plasmonic substrates with ultrahigh Q-factor resonances, Sci. Rep. 7 (2017) 15985.
[28] A. Chahkoutahi, et al., Sensitive Hemoglobin Concentration Sensor Based on Graphene‑Plasmonic Nano‑structures, Plasmonics. 17 (2022) 423–431.
[29] Y. Lu, H. Li, X. Qian, W. Zheng, Y. Sun, B. Shi and Y. Zhang, Beta-cyclodextrin based reflective fiber-optic SPR sensor for highly-sensitive detection of cholesterol concentration, Opt. Fiber Technol. 56 (2020) 102187. https://doi.org/10.1016/j.yofte.2020.102187.
[30] X. Fu, D. Li, Y. Zhang, G. Fu, W. Jin and W. Bei, High sensitivity refractive index sensor based on cascaded core-offset splicing NCF-HCF-NCF structure, Opt. Fiber Technol. 68, (2022) 102791.
[31] S. Gandhi, S. K. Awasthi and A. H. Aly, Biophotonic sensor design using a 1D defective annular photonic crystal for the detection of creatinine concentration in blood serum, RSC Adv. 11 (2021) 26655-26665.
