Precise Prognosis of Hypercholesterolemia and Acute Kidney Diseases by Photonic Crystal Biosensor
الموضوعات : فصلنامه نانوساختارهای اپتوالکترونیکی
1 - باشگاه پژوهشگران جوان دانشگاه آزاد اسلامی واحد بوشهر
الکلمات المفتاحية: Acute kidney injury, Biosensor, Cholesterol, Creatinine, Photonic crystal,
ملخص المقالة :
In this research, a two-dimensional photonic crystal based hexagonal shaped system is proposed. The presented device is made of 35*42 silicon rods (which are placed in the air medium). Basic functionality processes of the proposed biosensor were studied through photonic bandgap (PBG) and filed distribution diagrams. PBG and field spectra were obtained through plane wave expansion (PWE) and finite-difference-time-domain (FDTD) numerical methods, respectively. The designed system is considered for diagnosis of cholesterol and creatinine concentrations in blood samples (these biological elements are introduced through their refractive indices). At specific wavelengths (placed in TE PBG region), light wave could be transferred along the waveguide and would reach outputs 1 or 2. Output1 can be applied for diagnosis of cholesterol concentrations in blood with quality factor (Q): (55.2 – 66.4), sensitivity (S): 1204.7nm/RIU, detection limit (DL): (0.0021–0.0031) RIU and figure of merit (FOM): (48.18–54.6) RIU-1. Output2 would be considered for detection of creatinine in blood with quality factor (Q): (175.7–195.5), sensitivity (S): 1957.3nm/RIU, detection limit (DL): (4.8e-4 –5.2e-4) RIU and figure of merit (FOM): (184.8–205.9) RIU-1. Considering obtained results, proposed device (biosensor) would aid physicians in prognosis of hypercholesterolemia (which can cause heart diseases and strokes) and acute kidney injuries.
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