The effect of eight weeks of training on brain-derived neurotrophic index and insulin resistance in obese women with type 2 diabetes

Subject Areas : Effect of Physical Activity on Diseases

Bahman Hasanvand ¹ , firuz sharafi dehrahm ² , fatemeh ebrahimi ³

1 -
2 - Department of Physical Education and Sport Sciences, Faculty of Literature and Humanities, Islamic Azad University, Khorramabad Branch, Khorramabad, Iran
3 - 1- MSc in Exercise Physiology, Faculty of Literature and Humanities, Islamic Azad University, Khorramabad Branch, Khorramabad, Iran

Received: 2025-03-28 Accepted : 2025-07-02 Published : 2025-10-06

Keywords: Resistance training, brain-derived neurotrophic factor, insulin resistance, obesity, diabetes,

Abstract :

Background and Purpose: The present study was conducted to compare the effect of eight weeks of resistance training on brain-derived neurotrophic index and insulin resistance in obese women with type 2 diabetes in Noor Abad city.Materials and Methods: The subjects of this quasi-experimental study included 20 women with type 2 diabetes (mean age 42.6 ± 3.8 years) who were selected purposively and were randomly divided into two groups of 10: resistance training and control group.  48 hours before and 48 hours after the last training session, blood samples were taken from the subjects in both groups to assess brain-derived neurotrophic index and insulin resistance. Data analysis was performed using a paired t-test.Results: The results showed that resistance training significantly increased brain-derived neurotrophic factor (P=0.001) and significantly decreased insulin resistance (P=0.001) in the training group.Conclusion: Resistance training increased BDNF and consequently reduced neurological complications in patients with type 2 diabetes

References:

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