Cytogenetic study of infertile women with polycystic ovary syndrome, polycystic-diabetes and controls
Subject Areas : geneticsVarishe Qvrishi 1 , fatemeh keshavarzi 2 , Zahra Hooshmandi 3
1 - MS. Department of Biology, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran
2 - Associate Prof., Department of Biology, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran
3 - Assistant Prof., Department of Biology, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran
Keywords: Polycystic ovary syndrome, karyotype, chromosomal disorder, type 2 diabetes,
Abstract :
Introduction: Polycystic ovary syndrome is the most common endocrine disorder in women. The present study aimed to investigate the cytogenetics of infertile women with polycystic ovary syndrome (PCOS) and diabetes - PCOS.
Methods: Blood samples were taken from 83 women, including 61 affected women and 22 unaffected women of similar average age. Subsequently, the karyotype of these individuals was determined using cytogenetic methods.
Results: Out of the 61 individuals affected, 29 (47/5%) had only PCOS, while 42/5% had a family history of type 2 diabetes, gestational diabetes, or type 2 diabetes associated with PCOS in addition to PCOS. In the unaffected group, 18/2%, 9/1%, and 4/54% of women had a family history of type 2 diabetes, gestational diabetes, and type 2 diabetes, respectively. In the cytogenetic study of affected individuals, 91/9% had a normal phenotype, and 1/8% did not have a normal phenotype. This percentage did not show a significant association between PCOS and chromosomal abnormalities in the study sample. All 22 unaffected control women had a normal karyotype. When examining the demographic information of these patients, no significant association was observed between PCOS and type 2 diabetes or gestational diabetes. The association between diabetes and PCOS was examined in healthy and affected individuals, and despite a higher risk in affected individuals, no significant association was observed in any case (p > 0/05).
Conclusion: 1/8% of patients had an abnormal karyotype, but this percentage did not show a significant relationship between PCOS and chromosomal abnormalities in the sample size studied. However, it seems that cytogenetic karyotyping is crucial in cases related to PCOS, and this sample size cannot address the fundamental question of the issue.
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