A meta-analysis study of antibiotic resistance of Escherichia coli isolated from cases of bovine mastitis

majid mohammadsadeg ¹ ( )
Amir_Reza Yavarmanesh ² ( Doctor of General Veterinary Medicine, Department of Clinical Sciences, Faculty of Veterinary Medicine, Garmsar Branch, Islamic Azad University, Garmsar, Iran )

Submited date : 2025-01-30 Accepted date : 2025-06-28

Keywords: Metaanalisis, E coli, bovine mastitis, antibiotic resistance,

Abstract :

In this study, to investigate and analyze the meta-analysis of antibiotic resistance in Escherichia coli isolated from cows with mastitis, a total of 678 articles were extracted through scientific databases such as Google Scholar, PubMed, Web of Science, and Scopus using the keywords "antibiotic resistance," "bovine mastitis," and "E. coli." Subsequently, 111 articles were selected based on their titles, which were narrowed down to 71 in the initial screening and finally reduced to 27 articles. After selecting the final articles, a questionnaire was designed to extract information from each article. The results were then entered into Excel. The data analysis in this study was conducted in two sections: descriptive statistics and inferential statistics. In the descriptive statistics section, we described the number of studies and examined the prevalence rates to summarize the data. In the inferential statistics section, meta-analysis was performed using R software version 4.4.1. This study considered articles related to the prevalence of antibiotic resistance based on two classes: beta-lactams and aminoglycosides. Among the beta-lactam class, the antibiotic resistance to ampicillin was examined, while for the aminoglycoside class, the resistance to gentamicin was analyzed. The final conclusion indicates a wide range of variability in the prevalence of ampicillin- and gentamicin-resistant Escherichia coli in different studies. The final conclusion shows a scattered range in the prevalence of mixed Escherichia coli resistant to ampicillin and gentamicin in different studies.

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