Clay/APTS/Fe3O4 magnetic nanoparticles, as efficient catalysis with magnetic separation capability for the rapid synthesis of 2 amino 4h benzo[b]pyrans

Subject Areas : Applications of Nanostructures

Ghasem Rahpaima ¹ , Mohamadreza Nazarifar ² , Baharak Pooladian ³

1 - Department of Chemistry, Islamic Azad University, Lamerd Branch, Lamerd, Iran
2 - Department of Chemistry, Islamic Azad University, Lamerd Branch, Lamerd, Iran
3 - Department of Chemistry, Faculty of Science, Imam Khomeini International University, Qazvin, Iran

Received: 2024-10-22 Accepted : 2024-11-07 Published : 2025-01-20

Keywords: 2 amino 4h benzo[b]pyrans, Magnetite nanoparticles, Nanoclay, Heterogeneous catalyst, multicomponent reaction ,

Abstract :

Considering the wide application of benzopyran derivatives in industry and pharmaceuticals, in this study, the synthesis of 2-amino-H4-benzo[b]pyran derivatives from a one-step three-component reaction between various aromatic aldehydes, malononitrile and dimedone using magnetic nanoparticles Clay/APTS/Fe3O4 was introduced as an efficient catalyst, with magnetic separation capability, in ethanol and water solvent in a one-to-one ratio with excellent yield and very high purity. The products have been investigated using FT-IR and 1HNMR spectra. Clay/APTS/Fe3O4 exhibits several remarkable features such as extensive surface area for functional groups, durability, improved performance, reusability in the reaction without loss of catalytic activity and recyclability. In addition, other advantages that can be mentioned for this method include milder reaction conditions, cost-effectiveness, short reaction time, easy catalyst separation, avoidance of toxic waste generation, and simple work-up steps.

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