The Effect of High-intensity Interval Swimming with Gallic acid on mir-205 gene expression in the Reserpine-Induced Parkinson’s disease Rat Modle

Subject Areas :

Somayeh Rashidfard ¹ , Mehrzad Moghadasi ² , Mohammad Amin Edalatmanesh ³ , Sarah Hojjati ⁴

1 - Physical Education and Sport Science Department, Shiraz Azad University, Shiraz, Fars, Iran
2 - Associate professor in exercise physiology, department of exercise physiology, Shiraz branch, Islamic Azad University, Shiraz, Iran
3 - Department of Biology, Faculty of Basic Sciences, Islamic Azad University, Fars, Iran
4 - Assistant professor in exercise physiology, Department of Exercise physiology, Shiraz branch, Islamic Azad University, Shiraz, Iran

Received: 2024-09-27 Accepted : 2024-12-03 Published : 0001-01-01

Keywords: Parkinson’s disease, HIIT, Swimming, mir-205,

Abstract :

Purpose: The present study aimed to investigate the effect of six weeks of high-intensity interval swimming with Gallic acid on mir-205 gene expression in the hippocampal tissue of rats with Parkinson's disease model.

Research methodology: In this research, which was a basic experimental study, 35 male Wistar rats were divided into five groups: healthy control (n=7), diseased control (n=7), swimming (n=7), Gallic acid (n=7) and swimming+Gallic acid (n=7). The protocol of HIIT swimming and Gallic acid supplement was implemented with a regular program for six consecutive weeks. To investigate the expression of this gene in research groups, one-way and two-way ANOVA was applied through SPSS software version 26. The minimum level of significance in the tests was considered to be p<0.05.

Findings: The results of the Shapiro-Wilk test indicated the normal distribution of the mir-205 gene data. One-way ANOVA showed that there was no significant difference in the expression level of mir-205 gene between any of the groups (p=0.34 and F=1.21). In addition, the results of Two-way ANOVA indicated the absence of interaction between the two factors of HIIT swimming and Gallic acid supplementation on the expression of this gene in the hippocampal tissue of male rats with Parkinson's disease model.

Conclusion: In general, it can be said that high-intensity interval swimming with Gallic acid had no significant effect on mir-205 gene expression in the hippocampal tissue of male rats with Parkinson's disease model.

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