Study on the capacity of medicinal intake and release of the polymeric polyurethane and biological parts of pomegranate fruit nanocomposite

Subject Areas : journal of New Materials

Peyman Mohammadzadeh Jahani ¹ , Hooshang Hamidian ² , Ali Behrad Vakylabad ³ , Maedeh Jafari ⁴ , Samieh Fozuni ⁵ , Hanieh Sharafinejad ⁶

1 - Assistant professor of the school of medicine, Bam University of medical sciences, Bam, Iran.
2 - Associate Professor, Department of Chemistry, Payame Noor University (PNU), Kerman, Iran.
3 - Assistant professor, Department of Materials Science, Graduate University of Advanced Technology, Kerman, Iran.
4 - Assistant professor, Department of Pediatrics, School of medicine, Kerman University of medical sciences, Kerman, Iran.
5 - MSc graduate, Department of Chemistry, Payame Noor University (PNU), Kerman, Iran.
6 - MSc graduate, Department of Chemistry, Payame Noor University (PNU), Kerman, Iran.

Received: 2022-05-02 Accepted : 2023-01-09 Published : 2022-04-21

Keywords: Nanocomposite, Polyurethane, Biocompatibility, Meaty middling pomegranate, Pharmaceutical emission,

Abstract :

Introduction: Nanocomposites are used in biological research due to their unique properties like non-toxicity and biocompatibility. In this study, a new nanocomposite was prepared using polyurethane polymer, and the meaty middle part of the pomegranate which infixed with nano-silver particles.
Method: The nanocomposites containing polyurethane polymer, meaty shortcut part of pomegranate fruit, silver nanoparticles, and ciprofloxacin (drug) were chemically synthesized. SEM photomicrographs confirmed the presence of spherically dispersed silver nanoparticles. The combination of polyurethane with different weight percentages of pomegranate broiler was studied.
Results: The best performance for drug uptake (4.85 g/g) and release (0.45 g/l) was obtained using a combination of polyurethane polymer with 5 g of pomegranate middling meat, and 1 g of silver nanoparticles (NC3). SEM analysis determined the morphology and dispersion of nanoparticles. FTIR and XRD analysis showed specific peaks (at 2-thetas of 27.01, 38.103, 44.374, 64.541) of silver indicating successful synthesis of the nanocomposites. By studying the particle size distribution (PSD) of silver nanoparticles, SEM image analyses and XRD crystalline size analysis showed that there was a very good match between these two PSDs. This indicates the high dispersion of nanoparticles in composite paste without agglomeration, which was the main reason for the high efficiency of nanocomposite in drug adsorption and dispersion in an aqueous environment. The soluble calibration curve with specified percentages of this drug was used to measure the quantitative dissolution of ciprofloxacin. The maximum wavelength of ciprofloxacin absorption was 270 nm in UV-Vis spectrophotometry analysis.

References:

[1]          Mohammadzadeh Jahani, P., et al., Recycling Silver from Sarcheshmeh Copper Anodic Sludge for Green Synthesis of Silver-Based Nanocomposites. Journal of Mineral Resources Engineering, 2021. 6(2): p. 123-138.

[2]          Jordan, J., et al., Experimental trends in polymer nanocomposites—a review. Materials science and engineering: A, 2005. 393(1-2): p. 1-11.

[3]          Berta, M., et al., Effect of chemical structure on combustion and thermal behaviour of polyurethane elastomer layered silicate nanocomposites. Polymer Degradation and Stability, 2006. 91(5): p. 1179-1191.

[4]          Sanchez, C., et al., Applications of hybrid organic–inorganic nanocomposites. Journal of Materials Chemistry, 2005. 15(35-36): p. 3559-3592.

[5]          Jeong, B., et al., Thermoreversible gelation of poly (ethylene oxide) biodegradable polyester block copolymers. Journal of Polymer Science Part A: Polymer Chemistry, 1999. 37(6): p. 751-760.

[6]          Chen, T.K., J.Y. Chui, and T.S. Shieh, Glass transition behaviors of a polyurethane hard segment based on 4, 4 ‘-diisocyanatodiphenylmethane and 1, 4-butanediol and the calculation of microdomain composition. Macromolecules, 1997. 30(17): p. 5068-5074.

[7]          Zia, K.M., et al., Molecular engineering of chitin based polyurethane elastomers. Carbohydrate Polymers, 2008. 74(2): p. 149-158.

[8]          Manthiram, A., H.L. Marcus, and D.L. Bourell, Selective laser sintering using nanocomposite materials. 1995, Google Patents.

[9]          Fornes, T., et al., Nylon 6 nanocomposites: the effect of matrix molecular weight. Polymer, 2001. 42(25): p. 09929-09940.

[10]       Jose, A.J., M. Alagar, and A.S. Aprem, Thermal and barrier properties of organoclay-filled polysulfone nanocomposites. International Journal of Polymeric Materials, 2012. 61(7): p. 544-557.

[11]       Gyoo, P.M., S. Venkataramani, and S.C. Kim, Morphology, thermal, and mechanical properties of polyamide 66/clay nanocomposites with epoxy‐modified organoclay. Journal of applied polymer science, 2006. 101(3): p. 1711-1722.

[12]       Erdem, N., A.A. Cireli, and U.H. Erdogan, Flame retardancy behaviors and structural properties of polypropylene/nano‐SiO2 composite textile filaments. Journal of applied polymer science, 2009. 111(4): p. 2085-2091.

[13]       Alexandre, M. and P. Dubois, Polymer-layered silicate nanocomposites: preparation, properties and uses of a new class of materials. Materials science and engineering: R: Reports, 2000. 28(1-2): p. 1-63.

[14]       Merino, S., et al., Nanocomposite hydrogels: 3D polymer–nanoparticle synergies for on-demand drug delivery. ACS nano, 2015. 9(5): p. 4686-4697.

[15]       Xu, H., et al., Polymer encapsulated upconversion nanoparticle/iron oxide nanocomposites for multimodal imaging and magnetic targeted drug delivery. Biomaterials, 2011. 32(35): p. 9364-9373.

[16]       Abd-Rabou, A.A. and H.H. Ahmed, CS-PEG decorated PLGA nano-prototype for delivery of bioactive compounds: A novel approach for induction of apoptosis in HepG2 cell line. Advances in medical sciences, 2017. 62(2): p. 357-367.

[17]       Barikani, M., et al., Preparation and application of chitin and its derivatives: a review. Iranian Polymer Journal, 2014. 23(4): p. 307-326.

[18]       Feldman, D., Poly (Vinyl Alcohol) Recent Contributions to Engineering and Medicine. Journal of Composites Science, 2020. 4(4): p. 175.

[19]       Shirode, A.B., et al., Nanoencapsulation of pomegranate bioactive compounds for breast cancer chemoprevention. International journal of nanomedicine, 2015. 10: p. 475.

[20]       Heber, D., R.N. Schulman, and N.P. Seeram, Pomegranates: ancient roots to modern medicine. 2006: CRC press.

[21]       Benzie, I.F. and S. Wachtel-Galor, Herbal medicine: biomolecular and clinical aspects. 2011.

[22]       Gil, M.I., et al., Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing. Journal of Agricultural and Food chemistry, 2000. 48(10): p. 4581-4589.

[23]       Seeram, N., et al., Rapid large scale purification of ellagitannins from pomegranate husk, a by-product of the commercial juice industry. Separation and purification technology, 2005. 41(1): p. 49-55.

[24]       Larrosa, M., et al., Ellagitannins, ellagic acid and vascular health. Molecular aspects of medicine, 2010. 31(6): p. 513-539.

[25]       Mohseni, M.S., et al., Green synthesis of Ag nanoparticles from pomegranate seeds extract and synthesis of Ag-Starch nanocomposite and characterization of mechanical properties of the films. Biocatalysis and Agricultural Biotechnology, 2020. 25: p. 101569.

[26]       Ibraheem, D.R., et al., Ciprofloxacin-Loaded Silver Nanoparticles as Potent Nano-Antibiotics against Resistant Pathogenic Bacteria. Nanomaterials, 2022. 12(16): p. 2808.

[27]       Ganjouzadeh, F., S. Khorrami, and S. Gharbi, Controlled cytotoxicity of Ag-GO nanocomposite biosynthesized using black peel pomegranate extract against MCF-7 cell line. Journal of Drug Delivery Science and Technology, 2022. 71: p. 103340.

[28]       Amjad, A., A. Anjang Ab Rahman, and M.S.Z. Abidin, Effect of nanofillers on mechanical and water absorption properties of alkaline treated jute fiber reinforced epoxy bio nanocomposites. Journal of Natural Fibers, 2022: p. 1-17.

[29]       Zafar, N., et al., Moringa concanensis-Mediated Synthesis and Characterizations of Ciprofloxacin Encapsulated into Ag/TiO2/Fe2O3/CS Nanocomposite: A Therapeutic Solution against Multidrug Resistant E. coli Strains of Livestock Infectious Diseases. Pharmaceutics, 2022. 14(8): p. 1719.

[30]       Asadi, S., et al., Ciprofloxacin-Loaded Titanium Nanotubes Coated with Chitosan: A Promising Formulation with Sustained Release and Enhanced Antibacterial Properties. Pharmaceutics, 2022. 14(7): p. 1359.

[31]       Badinezhad, M., M. Soleimani, and S. Jafari, Stimuli responsive nano-composite co-delivery of Doxorubicin and ciprofloxacin using HPLC-UV combined spectroscopy methods. Materials Today Communications, 2022. 30: p. 103128.

[32]       Rami, M.R., et al., Synthesis of magnetic bio-nanocomposites for drug release and adsorption applications. South African Journal of Chemical Engineering, 2022. 42: p. 115-126.

[33]       Shariatinia, Z. and M. Ziba, Smart pH-responsive drug release systems based on functionalized chitosan nanocomposite hydrogels. Surfaces and Interfaces, 2022. 29: p. 101739.

[34]       Amjad, A., et al., Effect of nanofillers on mechanical and water absorption properties of alkaline treated flax/PLA fibre reinforced epoxy hybrid nanocomposites. Advanced composite materials, 2022. 31(4): p. 351-369.

[35]       Beygi, M., et al., Mechanical and Thermal Expansion Properties of Wood-PVC/LDPE Nanocomposite. Fibers and Polymers, 2022: p. 1-8.

[36]       Slowing, I.I., et al., Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers. Advanced drug delivery reviews, 2008. 60(11): p. 1278-1288.

[37]       Khan, Y.A., et al., Chitosan-alginate hydrogels for simultaneous and sustained releases of ciprofloxacin, amoxicillin and vancomycin for combination therapy. Journal of Drug Delivery Science and Technology, 2021. 61: p. 102126.

[38]       Orsu, P. and S. Matta, Fabrication and characterization of carboxymethyl guar gum nanocomposite for application of wound healing. International Journal of Biological Macromolecules, 2020. 164: p. 2267-2276.

[39]       Zafar, N., et al., Synthesis and characterization of potent and safe ciprofloxacin-loaded Ag/TiO2/CS nanohybrid against mastitis causing E. coli. Crystals, 2021. 11(3): p. 319.

[40]       Singh, J., S. Kumar, and A.S. Dhaliwal, Controlled release of amoxicillin and antioxidant potential of gold nanoparticles-xanthan gum/poly (Acrylic acid) biodegradable nanocomposite. Journal of Drug Delivery Science and Technology, 2020. 55: p. 101384.