The interaction of thiamine and zinc oxide nanoparticles on the renal parenchyma structure alterations
Subject Areas : Journal of Comparative Pathobiology
Rahmat alla Fatahian
1
(دانشیار گروه علوم پایه دانشکده دامپزشکی و پژوهشکده بیماری های مشترک انسان و دام دانشگاه شهرکرد . شهرکرد، ایران)
Behnaz Karimi
2
(Department of Biochemistry, Department of Basic Sciences, Shahrekord Faculty of Veterinary Medicine, Shahrekord, Iran)
Jahangir Kaboutari
3
(Department of Basic Sciences, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran.)
Reza Hoseini
4
(PhD student in veterinary medicine, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord-Iran)
kianoush Frouhar
5
(PhD student in veterinary medicine, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord-Iran)
Keywords: Mouse, Thiamine, Zinc oxide nanoparticles, Histology of biochemical reactions,
Abstract :
Along with the rapid development of nanomaterials technologies, zinc oxide nanoparticles are widely used in various aspects of human life. In this study, the histological changes of the kidney structure in the presence of thiamin were evaluated against the administration of zinc oxide nanoparticles in mice. 20 adult male Wistar rats were selected and randomly divided into 4 groups of 8. The first group, the control group; the second group, thiamine group (30 mg/kg of body weight); The third group, the group of zinc oxide nanoparticles (50 mg/kg of body weight) and the fourth group, the group of zinc oxide nanoparticles together with thiamine were considered. All injections were done intraperitoneally and all the conditions of animal rights were observed. At the end of the experiment, animal blood was taken to use the serum for biochemical tests and kidney tissue samples were taken to continue the slide preparation process. The results showed that obvious histological changes could be seen in the group of nanoparticles. Blood glucose and HDL showed a significant decrease in the nanoparticles group compared to the control group. On the other hand, cholesterol, LDL, BUN and creatinine showed a significant increase in the nanoparticles group compared to the control group. The simultaneous injection of nanoparticles with thiamine had reduced the tissue and biochemical changes largely. Thiamine can control the harmful effects of high dose of zinc oxide nanoparticles on all rats.
1. Khan I, Saeed K, Khan I. Nanoparticles: Properties, applications and toxicities. Arabian journal of chemistry. 2019;12(7):908-31.
2. Jain D, Shivani, Bhojiya AA, Singh H, Daima HK, Singh M, et al. Microbial fabrication of zinc oxide nanoparticles and evaluation of their antimicrobial and photocatalytic properties. Frontiers in chemistry. 2020;8:778.
3. Murali M, Kalegowda N, Gowtham HG, Ansari MA, Alomary MN, Alghamdi S, et al. Plant-mediated zinc oxide nanoparticles: Advances in the new millennium towards understanding their therapeutic role in biomedical applications. Pharmaceutics. 2021;13(10):1662.
4. Akhtar N, Ilyas N, Meraj TA, Pour-Aboughadareh A, Sayyed R, Mashwani Z-u-R, et al. Improvement of plant responses by nanobiofertilizer: a step towards sustainable agriculture. Nanomaterials. 2022;12(6):965.
5. Kumari L, Li W. Synthesis, structure and optical properties of zinc oxide hexagonal microprisms. Crystal Research and Technology: Journal of Experimental and Industrial Crystallography. 2010;45(3):311-5.
6. Zare M, Namratha K, Byrappa K, Surendra D, Yallappa S, Hungund B. Surfactant assisted solvothermal synthesis of ZnO nanoparticles and study of their antimicrobial and antioxidant properties. Journal of materials science & technology. 2018;34(6):1035-43.
7. Husen A. Natural product-based fabrication of zinc-oxide nanoparticles and their applications. Nanomaterials and plant potential. 2019:193-219.
8. Rasmussen JW, Martinez E, Louka P, Wingett DG. Zinc oxide nanoparticles for selective destruction of tumor cells and potential for drug delivery applications. Expert opinion on drug delivery. 2010;7(9):1063-77.
9. Lin D, Xing B. Phytotoxicity of nanoparticles: inhibition of seed germination and root growth. Environmental pollution. 2007;150(2):243-50.
10. Choi S-J, Choy J-H. Biokinetics of zinc oxide nanoparticles: toxicokinetics, biological fates, and protein interaction. International journal of nanomedicine. 2014;9(sup2):261-9.
11. Lin W, Xu Y, Huang C-C, Ma Y, Shannon KB, Chen D-R, et al. Toxicity of nano-and micro-sized ZnO particles in human lung epithelial cells. Journal of Nanoparticle Research. 2009;11:25-39.
12. Xia T, Kovochich M, Liong M, Madler L, Gilbert B, Shi H, et al. Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties. ACS nano. 2008;2(10):2121-34.
13. Carpenter KJ. The discovery of thiamin. Annals of Nutrition and Metabolism. 2012;61(3):219-23.
14. Amiri A, Dehkordi RAF, Heidarnejad MS, Dehkordi MJ. Effect of the zinc oxide nanoparticles and thiamine for the management of diabetes in alloxan-induced mice: a stereological and biochemical study. Biological trace element research. 2018;181:258-64.
15. Fatahian-Dehkordi R-A, Reaisi M, Heidarnejad M-S, Mohebbi A. Serum biochemical status and morphological changes in mice ovary associated with copper oxide nanoparticles after thiamine therapy. Journal of herbmed pharmacology. 2016;6(1):21-6.
16.
Rapala-Kozik M, Wolak N, Kujda M, Banas AK. The upregulation of thiamine (vitamin B 1) biosynthesis in Arabidopsis thaliana seedlings under salt and osmotic stress conditions is mediated by abscisic acid at the early stages of this stress response. BMC plant biology. 2012;12:1-14.
17. Gliszczyńska-Świgło A, Ciska E, Pawlak-Lemańska K, Chmielewski J, Borkowski T, Tyrakowska B. Changes in the content of health-promoting compounds and antioxidant activity of broccoli after domestic processing. Food Additives and Contaminants. 2006;23(11):1088-98.
18. Abouzeinab NS, Kahil N, Fakhruddin N, Awad R, Khalil MI. Intraperitoneal hepato-renal toxicity of zinc oxide and nickel oxide nanoparticles in male rats: biochemical, hematological and histopathological studies. EXCLI journal. 2023;22:619.
19. Sharma V, Singh P, Pandey AK, Dhawan A. Induction of oxidative stress, DNA damage and apoptosis in mouse liver after sub-acute oral exposure to zinc oxide nanoparticles. Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 2012;745(1-2):84-91.
20. Wang B, Feng W-Y, Wang T-C, Jia G, Wang M, Shi J-W, et al. Acute toxicity of nano-and micro-scale zinc powder in healthy adult mice. Toxicology letters. 2006;161(2):115-23.
21. Li J, Guo D, Wang X, Wang H, Jiang H, Chen B. The photodynamic effect of different size ZnO nanoparticles on cancer cell proliferation in vitro. Nanoscale research letters. 2010;5:1063-71.
22. Landsiedel R, Ma‐Hock L, Kroll A, Hahn D, Schnekenburger J, Wiench K, et al. Testing metal‐oxide nanomaterials for human safety. Advanced Materials. 2010;22(24):2601-27.
23. Li C-H, Shen C-C, Cheng Y-W, Huang S-H, Wu C-C, Kao C-C, et al. Organ biodistribution, clearance, and genotoxicity of orally administered zinc oxide nanoparticles in mice. Nanotoxicology. 2012;6(7):746-56.
24. Szebeni J. Hypersensitivity reactions to radiocontrast media: the role of complement activation. Current Allergy and Asthma Reports. 2004;4(1):25-30.
25. Umrani RD, Paknikar KM. Zinc oxide nanoparticles show antidiabetic activity in streptozotocin-induced Type 1 and 2 diabetic rats. Nanomedicine. 2014;9(1):89-104.
26. Nakayama A, Hiromura M, Adachi Y, Sakurai H. Molecular mechanism of antidiabetic zinc–allixin complexes: regulations of glucose utilization and lipid metabolism. JBIC Journal of Biological Inorganic Chemistry. 2008;13:675-84.
27. Al-Daraji HJ, Amen M. Effect of dietary zinc on certain blood traits of broiler breeder chickens. Int J Poult Sci. 2011;10(10):807-13.
28. Wang B, Feng W, Wang M, Wang T, Gu Y, Zhu M, et al. Acute toxicological impact of nano-and submicro-scaled zinc oxide powder on healthy adult mice. Journal of Nanoparticle Research. 2008;10:263-76.
29. Yan G, Huang Y, Bu Q, Lv L, Deng P, Zhou J, et al. Zinc oxide nanoparticles cause nephrotoxicity and kidney metabolism alterations in rats. Journal of Environmental Science and Health, Part A. 2012;47(4):577-88.
