Flaxseed oil Ameliorated the expression level of the IL-1β/NLRP3/NRF-1/Sirt-1of diabetic heart conditions.
Subject Areas : Exercise Physiology and PerformanceFarzad Forootan 1 , Fatemeh Zahra Abdollahi 2 , Mitra Shafie 3
1 - Legal Medicine Research Center, Legal Medicine Organization, Tehran, Iran.
2 - Department of Sports Physiology, Faculty of Sports Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran.
3 - Department of Plant Biotechnology, Medicinal Plants Research Centre, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran.
Keywords: cardiovascular diseases, Flaxseed, H9c2, genes,
Abstract :
Background: Inflammation and cytokine storms due to cardiovascular diseases (CD). Herbals can be the primary source of compounds with anti-inflammatory properties. Furthermore, herbals agents may consider as a complementary medicine. Bioactive compounds and phytochemicals have potential strategies to halt or manage CD. flaxseed have antioxidant and anti-inflammatory activity. Methods: In this study, we used H9c2 cell lines of rat embryonic cardiomyocytes. To induce CD we used hyperglycemic and hyperlipidemic conditions. Real-Time-PCR performed to evaluated the relative expression of the genes. Results: We found that flaxseed could decreased the expression level of the IL-1β and NLRP3. Moreover, the expression level of the NRF-1 and Sirt-1 increased by flaxseed. Conclusion: Our data proposed that flaxseed could have potential approaches to manage and prevent CD.
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