Investigation of the reparative effects of rosmarinic acid on experimental spinal cord injury in the Wistar rat animal model
Subject Areas : Developmental biology of plants and animals , development and differentiation in microorganisms
ahmad emadi
1
,
Hadi Naddaf
2
,
elham hoveizi
3
1 - 1- Student, Department of Clinical Sciences, Faculty of Veterinary, Shahid Chamran University of Ahvaz, Ahvaz, Iran
2 - Departement of clinical sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran
3 - گروه زیست شناسی، دانشکده علوم، دانشگاه شهید چمران اهواز، اهواز، ایران
Keywords: spinal cord injury, rosmarinic acid, neuroprotection, inflammation, animal model,
Abstract :
Spinal cord injury is a condition in which the spinal cord's parenchyma is damaged due to trauma or different diseases. Inflammatory reactions can indeed play a significant role in causing spinal cord injuries by altering the function of cells and leading to the death of nerve cells. Rosmarinic acid, a water-soluble polyphenolic phytochemical, possesses antioxidant, anti-inflammatory and anti-apoptotic properties. In this study, 12 Wistar rats were divided in two groups with equal populations. The control group did not receive any treatment after spinal cord injury until day 56, while the rosmarinic acid group received 100 mg/kg of rosmarinic acid extract in their drinking water daily until day 56 after the spinal cord injury. During the 56-day period, the mice were assessed for movement using the Basso, Beattie, and Bresnahan test. The group treated with rosmarinic acid showed higher scores in terms of movement recovery compared to the control group.The examination of tissue sections revealed that the group treated with rosmarinic acid exhibited significantly better recovery and repair, a reduction in the size of complications, and an increase in the myelination of nerve fibers at the spinal cord injury site compared to the control group (p<0.005). The research findings suggest that rosmarinic acid could potentially be a valuable therapeutic option for treating spinal injuries in the future. It's exciting to see the potential restorative effects of this compound in experimental studies on rats. This could pave the way for further exploration and development of new treatment options for spinal injuries.
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