The Effect of Milk Thistle (Silybum marianum) Consumption during Aerobic Exercise on Some Vascular Endothelial Indices in Women with Metabolic Syndrome

Subject Areas : Journal of Animal Biology

Elham Sadeghifar ¹ , Abdolali Banaeifar ² , Vahid Imanipour ³ , Sajad Arshadi ⁴

1 - Department of Physical Education and Sports Sciences, South Tehran Branch, Islamic Azad University, Tehran, Iran
2 - Department of Physical Education and Sports Sciences, South Tehran Branch, Islamic Azad University, Tehran, Iran
3 - Department of Physical Education and Sports Sciences, Parand Branch, Islamic Azad University, Parand, Iran
4 - Department of Physical Education and Sports Sciences, South Tehran Branch, Islamic Azad University, Tehran, Iran

Received: 2024-04-15 Accepted : 2024-06-29 Published : 2025-01-12

Keywords: Nitric oxide, Endothelial microparticles, Aerobic exercise, Milk thistle extract, Metabolic syndrome,

Abstract :

Obesity and related diseases are associated with cardiovascular. In this study, we aimed to assess the effect of aerobic exercise and milk Thistle extract on serum nitric oxide (NO) and endothelial microparticles (EMPs) in obese women with metabolic syndrome. In this quasi-experimental research, 48 obese women with metabolic syndrome, aged 35-40 years, were randomly divided into control (no intervention); milk thistle extract (280 mg /daily); exercise (aerobic exercise /every other day) and combined group (aerobic exercise + Milk thistle). Aerobic exercise and milk Thistle intake lasted for 8 weeks. Fasting NO and EMPs levels and anthropometric indices were measured before and after the intervention in all groups. Data were compared by ANCOVA between groups (p < 0.05). Compared to control group, serum NO significantly increased in the exercise and combined groups (p < 0.001). In combined group, serum NO and EMPs were significantly increased and decreased respectively in compared to other groups. The consumption of milk thistle extract during aerobic exercise is associated with more cardiovascular and endothelial effects than the application of each of them alone. Understanding the underlying mechanisms of these changes requires further studies in this field.

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