Determination of the diagnostic value of serum amyloid A, haptoglobin and some hematologic parameters in assessment of horse health

Subject Areas : clinical veterinary science

S.M Mortazavi ¹ , SH Safi ² , S.H Shirazi Beheshtiha ³ , وحید Rabani ⁴

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Received: 2016-11-15 Accepted : 2016-11-15 Published : 2012-06-21

Keywords: Health, horse, serum Amyloid A, haptoglobin,

Abstract :

  Acute phase proteins (APPs) are a class of serum proteins whose their concentration increase remarkably in response to infection,inflammation,trauma,neoplasia and etc.haptoglobin(HPt) and serum Amyloid (SAA) are to major APPs in horse.since,in farms, differentiation between healthy and sick horse is so important,the persent study was designed to determine the diagnostic value of APPs as sensitive biomarkers,and compare it with hematologic parameters for differentiation of healthy and sick horses in farm.according to the results of the present study, increase in the median of HPt and SAA was significant.with regard to the ROC curve,cutoff point of HPt and SAA was 0.829 and 0.6 ng/dl respectively and sensitivity and specificity in their cut off point was 86%, 87% for HPt and 84% , 73% for SAA. in addition, clinical accuracy of HPt and SAA,base of area under the curve,was 0907, 0.891 respectively. in other hand, significant difference between the clinical accuracy of HPt and SAA has not be seen.results of the present study show that HPt and SAA measurement can be used as a screening test to determine health status in horse.