Effect of Flunixin Meglumine injection on conception rate and plasma progesterone changes in Holstein heifers

Subject Areas : clinical veterinary science

M. Roostaie ¹ , , J Yadi ² , سعید Saeed Khalajzadeh ³

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Received: 2016-11-11 Accepted : 2016-11-11 Published : 2012-03-20

Keywords: progesterone, Ovsynch, conception rate, Flunixin Meglumine, PGF2a,

Abstract :

 The objective of this study was to examine the effects of administration of Flunixin Meglumine on conception rates and plasma progesterone(p4) changes in Holestein heifers and inhibition of PGF2a synthesis just before luteo lysis.32 Holstein heifers(15-month-old,BW:357+_5kg)were synchronized utilizing Ovsynch protocol and artificially inseminated.the heifers were assigned randomly to a treatment group(n=16) and a control group (n=16).the treatment group were injected intramuscularly three times on days 15.5,16 and 16.5 post insemination with 1.1 mg/kg bodyweight Flunixin Meglumine whereas control group received placebo.blood samples were collected on days 15.5,16 and 16.5 post insemination for analysis of plasma P4 concertrations.pregnancy was diagnosed on days 30 and 60 by transrectal ultrasonography.on day 30,10 of the treated heifers were pregnant compared with 4 of the control heifers(p<0.05):on day 60,9 of the treated heifers were still pregnant compared with 4 of the control heifers (p>0.05).maen plasma progesterone concentrations on day 16.5 in treated heifers (2.62+_0.66ng/ml-1) was higher than control group (1.87+_1ng/ml-1) but this improvement was not statistically significant(p>0.1).the results of this study support the hypothesis that Flunixin Meglumine is able to inhibit the uterine synthesis of PGF2a and increase the survival of early embryos.