Comparing effects of Glucosamine and Chondroitin sulphate combination with Naproxen on pain, physical function and radiologic findings in patients with knee osteoarthritis

Subject Areas : علوم پزشکی

Mohammad  Mahdi Nejad ¹ (استادیار، دانشکده پزشکی، دانشگاه آزاد اسلامی مشهد، مشهد، ایران)
Zahra  Jafari ² (دانشجوی رشته پزشکی، دانشکده پزشکی، دانشگاه ازاد اسلامی مشهد، مشهد، ایران)

Received: 2017-06-05 Accepted : 2017-06-05 Published : 2013-11-22

Keywords: knee osteoarthritis, Glucosamine- chondroitin sulphate, Naproxen,

Abstract :

Back groumd: Osteoarthritis (OA) is the most common type of arthritis. Its high prevalence, especially in the elderly, and the high rate of disability related to disease make it a leading cause of disability in the elderly. It is joint failure, a disease in which all structures of the joint have undergone pathologic change, often in concert and affects certain joints, yet spares others. The goals of the treatment of OA are to alleviate pain and minimize loss of physical function. To the extent that pain and loss of function. While nonpharmacologic approaches to therapy constitute its mainstay, pharmacotherapy serves an important adjunctive role in OA treatment. Available drugs are administered using oral, topical, and intraarticular routes. The use of glucosamine and chondroitin for OA has been controversial, and results of randomized trials have varied.  Objectives: Comparing effects of Glucosamine and Chondroitin sulphate combination with Naproxen on pain, physical function and radiologic findings in patients with knee osteoarthritis Method: Among patient with osteoarthritis (OA) who came to private clinic of researcher in mashad which their primary OA diagnosed by physical examination and radiography 240 people 40 – 60 years old participated  in this study. Patient divided in two groups based on age and gender . One group treated by naproxen and other group were under glucosamine cendroitin sulfate treatment. Results of treatment assessed after 12 an 15 month by kallegren and lawrance (K/L), VAS and Join Space width(JSW). Result: Two groups were similar to each other based on age(P=0/730), gender (P=0/603) and knee affected (P=0/195). According to VAS scale(P=0/262) and koos-ps(P=0/016) there were significant difference between NSAID and Glucosamine condroitin sulphate (GS) groups on pain and physical function . NASAID is more effective than GS. They have some difference quality in results of K/L and JSW over the period of time but at the end there were no difference between two groups. Conclusion:Although both NSAID and GS are effective on pain and physical function in patient with OA but due to the greater impact of NSAID and costs less than GS as well as the lack of GS on cartilageof the joint  NSAID is recommended.  

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