Protective Effect of aerobic exercise training along with hydroalcoholic cinnamon extract on inflammatory indicators and oxidative stress in rats fed a high-fructose drink
Subject Areas : Exercise Physiology and Performance
Fatemeh Hosseini
1
(Master of Sports Physiology, Department of Sport Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran.)
Fatemeh Noori
2
(Master of Sports Physiology, Department of Sport Physiology, Sari Branch, Islamic Azad University, Sari, Iran)
Ghasem Torabi Pelet Kale
3
()
Ahmad Abdi
4
(استادیار دانشگاه آزاد اسلامی واحد آیت الله آملی)
Rostam Abdi
5
(Department of Food Science and Technology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran)
Keywords: Exercise, Cinnamon, Insulin resistance, Inflammation and oxidative stress,
Abstract :
Background: Inflammatory indicators and oxidative stress play an important role in insulin resistance. The aim of this study was to investigate the effect of aerobic training with cinnamon extract on inflammatory indicators and oxidative stress in rats fed a high-fructose drink. Methods: Thirty-six Wistar male rats divided into groups: control (n=9), aerobic exercise (n=9), cinnamon extract (n=9), and aerobic exercise –cinnamon extract (n=9). Insulin-resistance status induced by %10 fructose solutions. Exercise groups subjected to a 5-day per week aerobic exercise program (with 75-80% VO2max) for 8 weeks. Extract groups subjected was Injected 200 mg/kgBW/day cinnamon extract. Data were analyzed using one-way ANOVA and statistical significance was set at p<0/05. Results: The results showed that aerobic training with or without extract caused to a significant decrease in serum TNF-α, IL-6 and CRP (p<0/05). Indeed, in all three experimental groups, SOD and GPX increased significantly compared to control (P<0.05). MDA levels also decreased significantly in experimental groups compared to control group (P<0.05). Conclusion: Results of this study indicated that aerobic exercise and cinnamon reduced inflammatory indicators and oxidative stress in rats fed a high-fructose drink. Also, cinnamon extract with aerobic exercise has a greater effect on these indicators.
1. Eriksson JW. Metabolic stress in insulin's target cells leads to ROS accumulation–a hypothetical common pathway causing insulin resistance. FEBS letters. 2007;581(19):3734-42.
2. De Luca C, Olefsky JM. Inflammation and insulin resistance. FEBS letters. 2008;582(1):97-105.
3. Lorenzo M, Fernández-Veledo S, Vila-Bedmar R, Garcia-Guerra L, De Alvaro C, Nieto-Vazquez I. Insulin resistance induced by tumor necrosis factor-α in myocytes and brown adipocytes 1 2. Journal of animal Science. 2008;86(14_suppl):E94-E104.
4. Li RW, Theriault AG, Au K, Douglas TD, Casaschi A, Kurowska EM, et al. Citrus polymethoxylated flavones improve lipid and glucose homeostasis and modulate adipocytokines in fructose-induced insulin resistant hamsters. Life sciences. 2006;79(4):365-73.
5. Botezelli JD, Coope A, Ghezzi AC, Cambri LT, Moura LP, Scariot PP, et al. Strength training prevents hyperinsulinemia, insulin resistance, and inflammation independent of weight loss in fructose-fed animals. Scientific reports. 2016;6:31106.
6. Stanišić J, Korićanac G, Ćulafić T, Romić S, Stojiljković M, Kostić M, et al. Low intensity exercise prevents disturbances in rat cardiac insulin signaling and endothelial nitric oxide synthase induced by high fructose diet. Molecular and cellular endocrinology. 2016;420:97-104.
7. Abdi A, Ramezani N, Abbasi Daloie A, Ganji N. The Effect of Aerobic Training and Coriandrum sativum Extract on Some Oxidative Stress Factors in Male Diabetic Wistar Rats. Tabari Journal of Preventive Medicine. 2017;2(4):34-43.
8. Hashem Dabaghian F, Kamalinejad M, Shojaii A, Abdollahi Fard M, Ghushegir SA. Review of Antidiabetic Plants in Iranian Traditional Medicine and their Efficacy. Journal of Medicinal Plants. 2012;1(41):1-11.
9. Chao LK, Hua K-F, Hsu H-Y, Cheng S-S, Lin I-F, Chen C-J, et al. Cinnamaldehyde inhibits pro-inflammatory cytokines secretion from monocytes/macrophages through suppression of intracellular signaling. Food and chemical toxicology. 2008;46(1):220-31.
10. Hagenlocher Y, Hösel A, Bischoff SC, Lorentz A. Cinnamon extract reduces symptoms, inflammatory mediators and mast cell markers in murine IL-10−/− colitis. The Journal of nutritional biochemistry. 2016;30:85-92.
11. Li R, Liang T, Xu L, Li Y, Zhang S, Duan X. Protective effect of cinnamon polyphenols against STZ-diabetic rat fed high-sugar, high-fat diet and its underlying mechanism. Food and chemical toxicology. 2013;51:419-25.
12. Pereira RM, Botezelli JD, da Cruz Rodrigues KC, Mekary RA, Cintra DE, Pauli JR, et al. Fructose consumption in the development of obesity and the effects of different protocols of physical exercise on the hepatic metabolism. Nutrients. 2017;9(4):405.
13. Fathi R, Aslani moghanjoughi S, Talebi Garakani E, Safarzadeh A, Seyghal H. EFFECT OF 8-WEEK RESISTANCE TRAINING ON PLASMA VISFATIN LEVELS AND ITS RELATION TO INSULIN RESISTANCE IN INSULIN-RESISTANT MALE RATS. Iranian Journal of Diabetes and Lipid Disorders. 2015;14(6):390-8.
14. Abbassi Daloii A, Fani F, Abdi A. The Effect of 8 weeks endurance training and L-NAME on Apelin in myocardial tissue and glucose elderly male’s rats. Razi Journal of Medical Sciences. 2016;23(145):22-9.
15. Modaresi M, Messripour M, Rajaei R. Effect of cinnamon extract on the number of spermatocyte and spermatozoa cells in rat. Iranian Journal of Medicinal and Aromatic Plants. 2010;26(1):83-90.
16. Mohamed MM, El-Halim SSA, El-Metwally EM. INSULIN RESISTANCE AND ADIPOCYTOKINE LEVELS IN HIGH FAT HIGH FRUCTOSE-FED GROWING RATS: EFFECTS OF CINNAMON. Egyptian Journal of Biochemistry & Molecular Biology. 2012;30(1).
17. Skovsø S. Modeling type 2 diabetes in rats using high fat diet and streptozotocin. Journal of diabetes investigation. 2014;5(4):349-58.
18. Mehran AE, Templeman NM, Brigidi GS, Lim GE, Chu K-Y, Hu X, et al. Hyperinsulinemia drives diet-induced obesity independently of brain insulin production. Cell metabolism. 2012;16(6):723-37.
19. Almind K, Kahn CR. Genetic determinants of energy expenditure and insulin resistance in diet-induced obesity in rat. Diabetes. 2004;53(12):3274-85.
20. Hammadi SH, AL-Ghamdi SS, Yassien AI, AL-Hassani SD. Aspirin and blood glucose and insulin resistance. Open Journal of Endocrine and Metabolic Diseases. 2012;2(02):16.
21. Kadoglou NP, Iliadis F, Angelopoulou N, Perrea D, Ampatzidis G, Liapis CD, et al. The anti-inflammatory effects of exercise training in patients with type 2 diabetes mellitus. European Journal of Cardiovascular Prevention & Rehabilitation. 2007;14(6):837-43.
22. Kristiansen OP, Mandrup-Poulsen T. Interleukin-6 and diabetes: the good, the bad, or the indifferent? Diabetes. 2005;54(suppl 2):S114-S24.
23. Kasapis C, Thompson PD. The effects of physical activity on serum C-reactive protein and inflammatory markers: a systematic review. Journal of the American College of Cardiology. 2005;45(10):1563-9.
24. Sreeja S, Geetha R, Priyadarshini E, Bhavani K, Anuradha CV. Substitution of soy protein for casein prevents oxidative modification and inflammatory response induced in rats fed high fructose diet. ISRN inflammation. 2014;2014.
25. Tuzcu Z, Orhan C, Sahin N, Juturu V, Sahin K. Cinnamon polyphenol extract inhibits hyperlipidemia and inflammation by modulation of transcription factors in high-fat diet-fed rats. Oxidative medicine and cellular longevity. 2017;2017.
26. Qin B, Polansky MM, Sato Y, Adeli K, Anderson RA. Cinnamon extract inhibits the postprandial overproduction of apolipoprotein B48-containing lipoproteins in fructose-fed animals. The Journal of nutritional biochemistry. 2009;20(11):901-8.
27. Kuhad A, Bishnoi M, Tiwari V, Chopra K. Suppression of NF-κβ signaling pathway by tocotrienol can prevent diabetes associated cognitive deficits. Pharmacology Biochemistry and Behavior. 2009;92(2):251-9.
28. Ho S-C, Chang K-S, Chang P-W. Inhibition of neuroinflammation by cinnamon and its main components. Food chemistry. 2013;138(4):2275-82.
29. Dehghan G, Shaghaghi M, Jafari A, Mohammadi M, Badalzadeh R. Effect of endurance training and cinnamon supplementation on post-exercise oxidative responses in rats. Molecular biology research communications. 2014;3(4):269.
30. Badalzadeh R, Shaghaghi M, Mohammadi M, Dehghan G, Mohammadi Z. The effect of cinnamon extract and long-term aerobic training on heart function, biochemical alterations and lipid profile following exhaustive exercise in male rats. Advanced pharmaceutical bulletin. 2014;4(Suppl 2):515.
31. Urso ML, Clarkson PM. Oxidative stress, exercise, and antioxidant supplementation. Toxicology. 2003;189(1-2):41-54.
32. Li X-L, Xu G, Chen T, Wong Y-S, Zhao H-L, Fan R-R, et al. Phycocyanin protects INS-1E pancreatic beta cells against human islet amyloid polypeptide-induced apoptosis through attenuating oxidative stress and modulating JNK and p38 mitogen-activated protein kinase pathways. The international journal of biochemistry & cell biology. 2009;41(7):1526-35.
33. Panda V, Mistry K, Sudhamani S, Nandave M, Ojha SK. Amelioration of Abnormalities Associated with the Metabolic Syndrome by Spinacia oleracea (Spinach) Consumption and Aerobic Exercise in Rats. Oxidative medicine and cellular longevity. 2017;2017.
34. Hosseini S, Shojaei S, Hosseini S. The effects of cinnamon on glycemic indexes and insulin resistance in adult male diabetic rats with streptozotocin. scientific magazine yafte. 2015;16(4):70-8.
35. Prasad KN, Yang B, Dong X, Jiang G, Zhang H, Xie H, et al. Flavonoid contents and antioxidant activities from Cinnamomum species. Innovative Food Science & Emerging Technologies. 2009;10(4):627-32.
36. Singh G, Maurya S, Catalan CA. A comparison of chemical, antioxidant and antimicrobial studies of cinnamon leaf and bark volatile oils, oleoresins and their constituents. Food and chemical toxicology. 2007;45(9):1650-61.
37. Sahin K, Orhan C, Tuzcu Z, Tuzcu M, Sahin N. Curcumin ameloriates heat stress via inhibition of oxidative stress and modulation of Nrf2/HO-1 pathway in quail. Food and chemical toxicology. 2012;50(11):4035-41.
38. Tanaka Y, Aleksunes LM, Yeager RL, Gyamfi MA, Esterly N, Guo GL, et al. NF-E2-related factor 2 inhibits lipid accumulation and oxidative stress in rat fed a high-fat diet. Journal of Pharmacology and Experimental Therapeutics. 2008;325(2):655-64.
39. Xie Q, Kashiwabara Y, Nathan C. Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase. Journal of Biological Chemistry. 1994;269(7):4705-8.
40. Wohleb ES, Godbout JP. Basic aspects of the immunology of neuroinflammation. Inflammation in psychiatry: Karger Publishers; 2013. p. 1-19.
41. Rose-John S. IL-6 trans-signaling via the soluble IL-6 receptor: importance for the pro-inflammatory activities of IL-6. International journal of biological sciences. 2012;8(9):1237.
