Comparing the Components between Parkinson's Disease Model in the Male Mice Induced by Rotenone
Subject Areas : Journal of Animal BiologyMohammad Mohammad Ali Mansouri 1 , Ahmad Ali Moazedi 2 , Gholam Ali Parham 3
1 - Department of Biology, Shahid Chamran University of Ahvaz, Ahvaz, Iran
2 - Department of Biology, Shahid Chamran University of Ahvaz, Ahvaz, Iran
3 - Department of Statistics, Shahid Chamran University of Ahvaz, Ahvaz, Iran
Keywords: Balance, Mice, Rotenone, Model of Parkinson', s disease, Muscle rigidity, Muscle strength,
Abstract :
Parkinson's disease (PD) is considered as a movement disorder, and its diagnosis is based on the presence of a set of cardinal motor symptoms. Since the pathogenesis of PD is not well understood today, the importance of the use of animal models to better understand PD and its cure is discovered. We aimed to provide new evidence on the comparison effect of rotenone on the components of PD. Thirty male mice (30±2 gr) were randomly divided into 3 groups; control group, rotenone solvent group, and rotenone group (ROT). ROT was treated with rotenone injections (2 mg/kg/48 h) for 19 days. Thus, the components of balance, movement, muscle rigidity and muscle strength tested by rotarod, open-field, and triple horizontal bar, and save testing data to evaluate and compare the effects of rotenone on these components. Component of muscle strength in all groups affected more than other components (P<0.05). In the next degree of balance, movement and muscle rigidity were affected. Rotenone could affect components of PD model which improved muscle strength component and was better than that of the other components. Probably this subject, including the main features of rotenone creates an experimental model of Parkinson's disease.
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