The Effect of Administration of Gold Nanoparticles on the Histology of Ovary in Wistar Rats

Subject Areas : Journal of Animal Biology

Khadijeh Fattahi ¹ , Arman Rostamzad ² , Salman Soltani ³ , Reza Hooshmandfar ⁴

1 - Department of Biology, Faculty of Science, Ilam University, Ilam, Iran
2 - Department of Biology, Faculty of Science, Ilam University, Ilam, Iran
3 - Histology Laboratory, Faculty of Science, Ilam University, Ilam, Iran
4 - Histology Laboratory, Faculty of Science, Ilam University, Ilam, Iran

Received: 2018-02-19 Accepted : 2018-02-19 Published : 2017-11-22

Keywords: Ovary, Gold Nanoparticle, Rat, Histology,

Abstract :

The gold nanoparticles like other nanoparticles have catalytic, magnetic, optical, and biological properties. Nowadays there is a little information on their impact on human health. The aim of this research was the histological study of ovary after administration of gold nanoparticles in Wistar rats. The total of 40 female Wistar rats was randomly divided into 4 groups: control (treated with 1 ml normal saline) and three experimental groups. Group 1, 2 and 3 received 1 ml of solution containing 10, 100, 1000 mg/kg gold nanoparticle by gavage for 15 successive days, respectively. The ovaries were removed from postnatal development; their weights were recorded and fixed in Bouin’s solution; subsequently, 6 µm serial paraffin sections were stained with haematoxylin-eosin; the structural changes of ovarian were studied. There was no significant difference on mean ovary of among all the treated, and control groups. There was no significant difference in the size of ovary, the average number of primary and secondary follicle among the 3 groups of rats (P<0.05). Therefore, gold nanoparticles at these concentrations and 60 nm size, do not effect on the ovary in Wistar rats

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