Effect of Different Doses of the Copper Nanoparticles on the Lung Tissue of the Male Wistar Rats

Subject Areas : Journal of Animal Biology

Ramezani N. N. ¹ , A. Shiravi ² , V. Hojati ³

1 - Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran
2 - Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran
3 - Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran

Received: 2017-06-17 Accepted : 2017-06-17 Published : 2017-05-22

Keywords: nanoparticles, Copper, Rat, Lung,

Abstract :

Nanoparticles are important in many aspects of human health applications. Given the lack of detailed documentation about the toxicity of silver nanoparticles, this study was conducted to investigate the effects of silver nanoparticles on lung tissue changes. In this study, 30 Wistar rats were divided into three groups of 10, control, experimental 1 and experimental 2, were studied. For the control group distilled water, for experimental group 1 to 20-nanometer particles at a concentration of 500 mg per kg and for experimental groups of 2 to 20 nm nanoparticles with a concentration of 1000 mg/kg was used by inhalation for 10 d were investigated. After 10 d, mice were sacrificed and their lung tissues were isolated and dissolved in acid. Silver deposits in lung tissues were measured using atomic absorption spectrophotometry. Statistical analysis showed that silver nanoparticles in lung tissues at doses of 500 and 1000 mg/kg, in comparison with the control group had significant changes and effects on lung tissues. Changes indicated the cell and tissue damages, respectively. Lung as one of the important organs in the body respiratory system can be a place deposition of silver nanoparticles.

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