The Effect of Panax ginseng Extract on Histomorphometric Changes on Cerebrum and Cerebellum in 14-Days Old Offspring Rats from Diabetic Mothers
Subject Areas : Journal of Animal Biology
A.
Karami
1
(Department of Biology, Payame Noor University, 19395-3697, Tehran, Iran)
Z.
Khaksar
2
(Department of Anatomy, Faculty of Veterinary, Shiraz University, Shiraz, Iran)
Keywords: Diabetes mellitus, Cerebrum, Streptozotocin, Cerebellum, Panax ginseng extract,
Abstract :
Gestational diabetes is a variable amount of glucose intolerance initially diagnosed or diagnosed during pregnancy and can induce developmental disorders in different parts of CNS. We investigated the effect of extract of Panax ginseng on histomorphometric changes oncerebrum and cerebellum in 14 d offspring'srat from diabetic mothers. Sixteen rats were divided into four groups: non-diabetic control, non-diabetic recipient of the extract, diabetic control and diabetic recipient of the extract. Diabetes was induced by streptozotocin in diabetic groups and all 4 groups became pregnant. During the pregnancy, recipient of the extract groups received Ginseng extract at the dose of 400 mg/kg of body weight every day. Overall, 14 d of normal delivery; offspring's were anesthetized. The cerebrum and cerebellum were removed by cutting the skull. After using the techniques of histology, some histological factors were measured. Data were analyzed using SPSS software and ANOVA and Duncan statistical tests. A significant reduction was observed in gray matter thickness and cell count of cerebrum and white matter cell count of cerebellum in diabetic control group than non-diabetic groups (P≤0.05). In addition, a significant reduction was observed in white matter cell count of cerebrum in diabetic control group than other groups (P≤0.05). Extract of P. ginseng could control hyperglycemia and manage diabetes on the cerebrum and cerebellum disorders in offspring's of mothers with gestational diabetes by increasing β-cells stimulation and increase insulin production.
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