The Histopathological Evaluation of the Effect of Chia Seed Extract on Bone Fusion in Rabbit Animal Model

Subject Areas : Journal of Animal Biology

Milad Mohammadi ¹ , Elham Moghtadaiee ² , Moosa Javdani ³

1 - Department of Veterinary Medicine, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran.
2 - Department of Pathobiology, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran.
3 - Department of Clinical Sciences, Shahrekord University, Shahrekord, Iran.

Received: 2022-01-03 Accepted : 2023-01-31 Published : 2022-11-22

Keywords: Histopathology, Radius bone, Chia seeds, Bone fusion,

Abstract :

Bone fracture is one of the most common cases in animals and even in humans. Various methods have been used to treat and repair fractures. The prevalence of fractures and the time-consuming methods used today have led us to come up with a new way to treat animals faster. For this purpose, 5 New Zealand male rabbits weighing 0.5-1.5 kg were selected and kept for six weeks. After anesthesia under sterile conditions, the skin was exposed to the radius bones and excised part of the bone. After receiving antibiotics, the rabbits were divided into 5 groups, each containing treatment and control, and received 30 mg / kg and 1 mg / kg of chia seed extract for thirty days and they were examined histopathologically during week 1 and 2, and 3. The pathology of this study showed that the dosage of 1mg / kg had better healing effects compared with the other groups from the fourth week and bone mineral density was more evident. According to the results of this study, chia seeds can be a substitute for chemical pharmaceutical supplementation to repair bone defects.                                                      

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