Evaluation of the Effect of Satureja Edmondi on the Level of Pituitary-gonadal Hormones in Normal Rats and Those Induced by Chemical Kindling with Pentylenetetrazole

Subject Areas : Journal of Animal Biology

Somayeh  Bohlouli ¹ (Department of Veterinary Medicine, Kermanshah Branch, Islamic Azad University, Kermanshah, Iran)
Gelavij  Mahmoodi ² (Department of Biology, Kermanshah Branch, Islamic Azad University, Kermanshah, Iran)

Received: 2020-10-13 Accepted : 2021-01-13 Published : 2021-08-23

Keywords: Rat, Pentylenetetrazole, Satureja Edmondi, Pituitary-gonadal hormones,

Abstract :

Epilepsy is a neurological disorder that occurs in both men and women, but is more likely to occur in men than women. Epilepsy and many antiepileptic drugs cause reproductive disorders and reduce the quality of semen in men and increase the risk of infertility in men with epilepsy. some medicinal plants prevents the progression of the disease and the occurrence of epileptic seizures. The aim of this study was to evaluate the effect of Satureja edmondi on the level of pituitary-gonadal hormones in normal and epileptic rats with pentylenetetrazole. In this study, 48 Wistar rats were used. Rats were divided into two groups: normal and kindling with pentylenetetrazole, and each group was divided into three subgroups, control and treated with doses of 150 and 300 ppm Satureja edmondi essential oil. After 4 weeks, rats were examined for pituitary-gonadal hormone levels. Data analysis was performed by one-way ANOVA method and Tukey post hoc test and P

References:

1. Abdollahi M., Salehnia A., Mortazavi  S.H.R., Ebrahimi M., Shafiee A., Fouladian F., Keshavarz K., Sorouri S., Khorasani R., Kazemi A. 2003. Antioxidant, antidiabetic, anti-hyperlipidemic, reproduction stimulatory properties and safety of essential oil of Satureja khuzestanicain rat in vivo: a toxicopharmacological study. Medical Science Monitor, 9(9): 331-335.

1. Acharya U.R., Sree S.V., Swapna G., Matris R.J., Suri J.S. 2013. Automated EEG analysis of epilepsy: A review. Knowledge-Based Systems, 45: 147-165.


2. Atif M., Sarwar M.R., Cahill S. 2016.The relationship between epilepsy and sexual dysfunction: a review of the literature. Springerplus, 5(1): 2070.


3. Bohlouli S., Rostaminasab G. 2019. Effect of hydroalcoholic extract of Ferolla goangulata on sperm and testosterone indices in male rats .Journal of Ilam University of Medical Sciences, 3(3): 47-55. [in Persian]


4. Cao L., Leers-Sucheta S., Azhar S., 2004. Aging alters the functional expression of enzymatic and non-enzymatic anti-oxidant defense systems in testicular rat Leydig cells. The Journal of Steroid Biochemistry and Molecular Biology, 88(1): 61-67


5. Ebisch IM., Thomas CM., Peters WH., Braat RP., Theunissen S., 2007. The importance of folate,zinc and antioxidants in the pathogenesis andprevention of subfertility. Human Reproduction Update, 13(2): 163-174.


6. Erkec Ö.E., Arihan O. 2015.  Pentylenetetrazole Kindling Epilepsy Model. Epilepsi, 21(1): 6-12.


7. Fukushima T., Hamada Y., Komiyama M., Matsuno Y., Mori C., Horii I. 2007. Early changes in sperm motility, acrosome reaction, and gene expression of reproductive organs in rats treated with sulfasalazine. Reproductive Toxicology, 23(2): 153-157.


8. Isojärvi J., Löfgren E., Juntunen K., Pakarinen A., Päivänsalo M., Rautakorpi I., Tuomivaara L. 2004. Effect of epilepsy and antiepileptic drugs on male reproductive health. Neurology, 62(2): 247-253.


9.  Liu W., Ge T., Pan Zh., Leng Y., Lv J., Li B. 2017. The effects of herbal medicine on epilepsy. Oncotarget, 8(29): 48385-48397.


10.  Makker K., Agarwal A., Sharma R. 2009. Oxidative stress & male infertility. Indian Journal Medical Research, 129(4): 357-367.


11.  Mehrabi-Nasab E., Khazaei M., Khazaei S. 2010. The effect of pentylene tetrazol kindling induced epilepsy on hypogonad hormones and sperm parameters of rats. Arak University of Medical Sciences Journal, 12(4): 105-112. [in Persian]


12.  Moradi S., Sadeghi E. 2017. Study of the antimicrobial effects of essential oil of Saturejaedmondi and nisin on Staphylococcus aureus in commercial soup. Journal of Food Processing and Preservation,41(4): e13337


13.  Najafi G., Farokhi F., ShalizarJalali A., Akbarizadeh Z. 2016.Protection against cyclosporine-induced reprotoxicity by Satureja khuzestanica essential oil in male rats. International Journal of Fertility and Sterility, 9(4): 548-557.


14.  Omrani A., Ghadami M.R., Fathi N., Tahmasebian M., Fatholahi Y., Touhidi A. 2007. Naloxane improve impairment of spatialperformance induced pentenyle tetrazol kindeling in rats. Neuroscience, 145(3): 824-831.


15.  Ocek L., Tarhan H., Uludağ F.I., Sarıteke A., Köse C., Colak A. 2018. Evaluation of sex hormones and sperm parameters in male epileptic patients. Acta Neurolgica Scandinavica, 137(4): 409-416.


16.  Pennell P.B. 2009. Hormonal Aspects of Epilepsy. Neurologic Clinics, 27(4): 941-965.


17.  Pook M., Tuschen-Caffier B., Krause W. 2004. Is infertility a risk factor for impairedmale fertility? Human Reproduction, 19(4): 954-959.


18.  Pourmotabbed A., Mahmoodi G., Mahmoodi S., Mohammadi Farani A., Nedaei S.E., Pourmotabbed T. 2014.  Effect of central muscarinic receptors on passive- avoidance learning deficits induced by prental pentylene tetrazol kindling in male offspring. Neuroscience, 279: 232-237.


19.  Rostami-Nassab G., Bohlouli S., Ghanbari A. 2018.  Therapeutic effect of Ferula goangulata extractonreproductive parameters and serum testosterone levels in diabetic male rats. Journal Reports in Pharmaceutical Sciences, 7(1): 1-8.


20.  Safarnavadeh T., Rastegarpanah M. 2011. Antioxidants and infertility treatment, the role of Satureja khuzestanica: A mini-systematic review. Iranian Journal of Reproductive Medicine, 9(2): 61-70.


21.  Zhang Z., Liao L., Moore J., Wu T., Wang Z. 2009. Antioxidant Phenolic Compounds from Walnut Kernels (Juglans regia L.). Food Chemistry, 113(1): 160-165.