Effect of Resveratrol on Testicular Damage in Streptozotocine-induced Diabetic Rats

Subject Areas : Journal of Animal Biology

آزاده شریف خطیبی ¹ , عبدالحسین شیروی ² , حمید کلالیان مقدم ³

1 - گروه زیست شناسی، واحد دامغان، دانشگاه آزاد اسلامی، دامغان، ایران
2 - گروه زیست شناسی، واحد دامغان، دانشگاه آزاد اسلامی، دامغان، ایران
3 - گروه فیزیولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی شاهرود، شاهرود، ایران

Received: 2015-06-16 Accepted : 2017-05-21 Published : 2015-04-21

Keywords: Spermatogenesis, Rat, Resveratrol, Diabetes,

Abstract :

Diabetes disease produces free radicals and oxidative stress serves plays an important role in creating many of behavioral variations metabolic damage played, leading to testicular damage This study have shown resveratrol due to having antioxidant and anti apoptosis properties plays an important role to prevent and care of oxidative stresses therefore, this research investigates through beneficial effects of resveratrol on testicular damages in diabetic male rats induced by streptozotocin. In the current study 32 of male Wister rats, weight range of 250 g to 280 g were selected and divided into 4 groups: 1) Diabetic group, 2) Diabetic group + resveratrol treat, 3) Control group and 4) Control group + resveratrol treat. Diabetes was induced by stz injection (55 mg/kg). Resveratrol was injected at the dose 10 mg/kg for 4 week. In the fourth week, testicular damages were studied using hematoxylin and eosin staining. In the resveratrol treated group morphologic changes made by diabetic is dramatically decreased. On the other hand deteriorative cells are significantly increased the diameter are decreased the first study showed that talking resveratrol, testicular damage in diabetic rats significantly reduced. Ability of resveratrol to treat preventable and oxidative stress plays role in improving the testicular damage, resveratrol can decreased weight and glucose.