Evaluation of plasma changes of hepcidin, total sialic acid and sphingosine 1 phosphate in buffaloes with hepatic hydatidosis
Subject Areas : Clinical PathologyOmid Mohammadpour 1 , Sohrab Rasouli 2 , Kaveh Azimzadeh 3 , Maryam Salarpour 4 , Ariyan Narouie 5
1 - Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran
2 - Department of pathobiology, Veterinary Faculty, Urmia Branch, Islamic Azad University, Urmia, Iran
3 - Department of Clinical Sciences, Veterinary Faculty, Urmia Branch, Islamic Azad University, Urmia, Iran
4 - Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran
5 - Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran
Keywords: Buffalo, hydatidosis, Hepcidin, total sialic acid, Sphingosine 1 phosphate,
Abstract :
The aim of this study was to evaluate plasma changes in hepcidin, total sialic acid (TSA) and sphingosine 1 phosphate (S1P) in buffalos with hydatidosis in the city of Urmia. Hydatidosis is a zoonotic disease that can be very dangerous in humans and even cause death to humans and animals. In this study, the samples were taken from 40 cases of buffalos that suffered from hydatidosis, especially the liver form of the disease, and also 40 buffaloes without hydatidosis all taken from Urmia slaughterhouse. After the separation of plasma samples, the mentioned parameters were measured and analyzed statistically using SPSS version 17. The results indicated a significant increase P<0.05 in all mentioned parameters compared to the healthy group. Based on the above result, it can be noted that hydatidosis causes changes in plasma levels of some parameters. Interpreting some of the parameters would help us come to a better understanding of the complications of the disease. Furthermore, focusing on these parameters along with other plasma parameters would help practitioners in the paraclinical diagnosis of buffalo’s hydatidosis.
[1] Barras V, Greu b G, History of biological warfare and bioterrorism. Clin. Microbiol. Infect. 2014; 20(6), 497–502.
[2] Christian MD, Biowelfare and bioterrorism. Crit. Care Clin. 2013; 29, 717–756.
[3] Hame le M, Poss WB, Sweney J, Disaster prepardness,pediatric considerations in primary blast injury, chemical,and biological terrorism. World J. Crit. Care Med. 2014; 3,15–23.
[4] Klietmann WF, Ruoff KL, Bioterrorism: implications for theclinical microbiologist. Clin. Microbiol. Rev. 2001,14, 364–381,.
[5] Rotz LD et al., Public health assessment of potential biological terrorism agents. Emerg. Infect. Dis. 2002; 8, 225–230.
[6] Anderson RC, Nematode parasites of vertebrates. Theirdevelopment and transmission. CAB International, Wallingford, Oxon, 2000.
[7] Anderson RC, Cha baud AG Willmot S, Key to the nematodes of vertebrates. CABI Publishing, Wallinford, UK, 2009.
[8] Ash LR, Orihel TC, Atlas of human parasitology, 3rd edition. ASCP Press, Chicago, 1990.
[9] Ash LR, Orihel TC Parasites. A guide to laboratory procedures and identification. ASCP Press, Chicago, 1987.
[10] Barrat JL et al., The ambiguous life of Dientamoeba fragilis: the need to investigate current hypotheses on transmission. Parasitology. 2011; 135,557–572.
[11] Brown D et al., (eds.), Zoonoses. 2nd ed. Oxford UniversityPress, Oxford, 2011.
[12] Bu rgess NRH, Cowan GO, A colour atlas of medical entomology. Chapman & Hall, London, 1993.
[13] Dorny P et al., Emerging food-born parasites. Vet. Parasitol. 2009; 163, 196–206.
[14] Deplaces P et al., Lehrbuch der Parasitologiefür die Tiermedizin. 3. Aufl. Enke-Verlag Stuttgart, 2012.
[15] Garcia LN, Bruckner DA, Diagnostic medical parasitology, 4th edition. ASM Press, Washington, DC, 2001.
[16] Hiepe T, Lucius R Gottstein B, Allgemeine Parasitologie.Parey, Stuttgart, 2006.Isenberg HD (ed.), Essential procedures for clinical microbiology. ASM Press, Washington, DC, 1998.
[17] Kenney M, Yermakov V, Infection of man with Trichurisvulpis, the whipworm of dogs. Am. J. Trop. Med. Hyg. 1980; 29,1205–1208.
[18] Kettle PS, Medical and veterinary entomology. CAB International, Wallingford, 1990. Lane RP, Crossey RW (eds.), Medical insects and arachnids.Chapman & Hall, London 1995.
[19] Lobato J et al., Detection of immunoglobulin G antibodiesto Neospora caninum in humans: high seropositivy rates in patients who are infected by human immunodeficiency virus or have neurological disorders. Clin. Vaccine Immunol. 2006; 13, 84–89.
[20] Macpherson CN, Human behaviour and the epidemiology of parasitic zoonoses. Int. J. Parasitol. 2005; 35, 1319–1331.
[21] McCann CM et al., Lack of serologic evidence of Neosporacaninum in humans, England. Emerg. Infect. Dis. 2008; 14,978–980.
[22] Thudichum JLW. A treatise on the chemical constitution of the brain with a new historical introd. In: Drabkin David L, ed. Hamden, Conn. Archon Books; 1962.
[23] Hannun YA, Obeid LM. Principles of bioactive lipid signalling: lessons from sphingolipids. Nat Rev Mol Cell Biol. 2008; 9:139–150.
[24] Spiegel S, Milstien S. The outs and the ins of sphingosine-1-phosphate in immunity. Nat Rev Immunol. 2011; 11:403–415.
[25] Hanada K, Kumagai K, Tomishige N, Yamaji T. CERT-mediated trafficking of ceramide. Biochim Biophys Acta. 2009; 1791:684–691.
[26] Rao RP, Acharya JK. Sphingolipids and membrane biology as determined from genetic models. Prostag Other Lipid Mediat. 2008; 85:1–16.
[27] Ng ML, Wadham C, Sukocheva OA. The role of sphingolipid signalling in diabetesassociated pathologies (Review). Int J Mol Med. 2017 ;39:243–252.
[28] Guzel M, Askar TK, Kaya G, Atakisi E, Erbil Avci G: Serum sialic acids,total antioxidant capacity, and adenosine deaminase activity in cattlewith therliriosis and anaplasmosis. Bull Vet Inst Pulawy. 2008; 52, 227-230.
[29] Citil M, Gunes V, Karapehlivan M, Atalan G, Marasli S: Evaluation of serum sialic acid as an inflmmation marker in cattle with traumatic reticulo peritonitis. Rev Med Vet. 2004; 155, 389-392.
[30] Yurtsevan S, Uysal H: Decreased serum sialic acid, albumin-globulin ratio and total protein levels in cattle heavily infected with Theileria annulata. Ankara Üniv Vet Fak Derg, 2009; 56, 141-144.
[31] Chrostek L, Cylwik B, Panasiuk A, Brodowska-Adamusiak D,Gruszewska E: Lipid-bound sialic acid (LSA) in liver diseases of diffrent etiologies. Annal Hepatology J. 2011; 10, 150-154.
[32] Adams, P.C., Kertesz, A.E., McLaren, C.E., Barr, R., Bamford, A., and Chakrabarti, S. Hepatology. 2000; 31, 1160–1164.
[33] Komano, H, Fujiura, Y Kawaguchi, M, Matsumoto S, Hashimoto Y, Obana S, and et al. Proc. Natl. Acad. Sci. USA. 1995; 92, 6147–6151.
[34] Ganz T. Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation, Blood. 2003; 102: 783-788.
[35] Citil M,Gunes V, Karapehlivan M, Atalan G, Marasli S: Evaluation of serum sialic acid as an inflammation marker in cattle with traumatic reticulo peritonitis. Rev. Med. Vet-Toulouse, 2004; 155, 389-392.
[36] Chrostek L, Cylwik B, Panasiuk A, Brodowska-Adamusiak D, Gruszewska E: Lipid-bound sialic acid (LSA) in liver diseases of different etiologies. Annal. Hepatology.J. 2011; 10, 150-154.
[37] Stefenelli N, Klotz H, Engel A, Bauer P: Serum sialic acid in malignant tumors, bacterial infections and chronic liver diseases. J Cancer Res Clin Oncol. 1985; 109, 55-59.
[38] Yurtsevan S, Uysal H: Decreased serum sialic acid, albumin-globulin ratio and total protein levels in cattle heavily infected with Theileriaannulata. Ankara. Üniv. Vet. Fak. Derg. 2009; 56, 141-144.
[39] Hait,N.C. , Oskeritzian ,C.A, Paugh , S.W, Milstien, Speiegel, S. .Sphingosine Kinase ,sphingosine 1-phosphate, apoptosis and disease .Biochimical et Biophisica Acta. 2006; .1758: 2016-2026.
[40] Guzel M, Askar TK, Kaya G, Atakisi E,Avci GE. Serum sialic acids, totalantioxidant capacity, and adenosinedeaminase activity in cattle with theileriosisand anaplasmosis. Bull Vet Inst Pulawy. 2008; 52:227-30.
[41] Tan TCH, Crawford D, Franklin M,Jaskowski L, Macdonald GA, Jonsson J. The serum hepcidinferritin ratio is apotential biomarker for cirrhosis. Liver Int. 2012; 32:1391-9.
[42] Lauth X, Babon JJ, Stannard JA, SinghS, Nizet V, Carlberg JM. Basshepcidin synthesis, solution structure,antimicrobial activities and synergism, andin vivo hepatic response to bacterialinfections. J Biol Chem 2005; 280: 9272-82.
[43] De Mast Q, Syafruddin D, Keijmel S,Riekerink TO, Deky O, Asih PB.Increased serumhepcidin and alterations inblood iron parameters associated withasymptomatic P.falciparum and P. vivaxmalaria. Haematologica 2010; 95:1068-74.
[44] Wu TW, Tabangin M, Kusano R, Ma Y,Ridsdale R, Akinbi H. The utility of serumhepcidin as a biomarker for late-onsetneonatal sepsis. J Pediatrics. 2013; 162:67-71.
[45] Strnad P, Schwarz P, Rasenack MC,Kucukoglu O, Habib RI, Heuberger D. Hepcidin is an antibacterial,stressinducible peptide of the biliarysystem. Plos One. 2011; 6:6454.
[46] Cherian S, Forbes DA, Cook AG,Sanfilippo FM, Kemma EH, Swinkels DW. An insight into the relationshipsbetween hepcidin, anemia infections andinflammatory cytokines in pediatricrefugees a cross-sectional study. Plos One. 2008; 3:4030.
[47] Kossiva L, Soldatou A, Gourgiotis D,Stamati L, Tsentidis C. Serum hepcidinindication of its role as an acute phasemarker in febrile children. Italian J Pediatr. 2013; 39:25-30.
[48] Ashrafian H. Hepcidin: the Missing Link between Hemochromatosis and Infections, Infect. Immun. 2013; 71(12): 6693-6700.
