Abstract :
A simple, rapid, and inexpensive dispersive liquid-liquid microextraction based on solidification of organic drop (DLLME-SFO) combined with high-performance liquid chromatography was developed for the extraction and determination of trace levels of atorvastatin (ATV) in tablet. Effect of variables such as extracting and dispersive solvent volume and pH were investigated simultaneously using experimental design. Under the optimum conditions, the calibration graph was linear in the range of 1-200 μg L-1 with the detection limit of 0.3 μg L-1. The optimized method revealed a good precision with relative standard deviation (RSD) of2.2 %.The performance of the method was evaluated for extraction and determination of ATV in tablet sample. The results of this study revealed that the proposed method gives high extraction efficiency and low LOD. The most important advantage of this technique is that the use of large sample volumes and toxic organic solvents have been omitted.
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