Application of homogenizer assisted dispersive liquid-phase microextraction in combination with ion mobility spectrometry for the determination of mefenamic acid in different samples

Subject Areas :

Sama  Hayatkhah ¹ (University of Zanjan)
Bahman  Farajmand ² (Department of Chemistry, Faculty of Science, university of Zanjan, Zanjan, Iran)
Mohammad Reza  Yaftian ³ (Department of Chemistry, Faculty of Science, University of Zanjan,)

Received: 2020-09-30 Accepted : 2021-04-17 Published : 2021-11-22

Keywords: Mefenamic acid, Ion mobility spectrometry, Dispersive liquid phase microextraction, Homogenizer,

Abstract :

In this study, the combination of homogenizer-assisted dispersive liquid-liquid microextraction and ion mobility spectrometry has been introduced as a rapid and sensitive method for the determination of mefenamic acid. Effective parameters of the method such as pH, ionic strength of the sample, homogenization rate and time, type and volume of extraction solvent have been investigated and optimized. Optimal conditions were obtained by applying 50 µl chloroform solvent at 8 second homogenization time for 16000 rpm at pH equal to 5 and salt addition at 0.15 g/ml. The analytical performances of the method including linear range, detection limit, repeatability, and enrichment factor were evaluated under optimal conditions. The calibration curve was linear in the range of 10 to 500 μg/L. The inter-day and intra-day relative standard deviations were 9.8% and 8.1%, respectively. The limit of detection for the analyte was 3.1 µg/L. Relative recoveries were obtained in the range of 92 to 111% for river water, 88 to 107% for urine, and 92 to 106% for milk samples.

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