The Study of Association of ACVR2A rs1424941 polymorphism with preeclampsia in Iranian patients
Subject Areas : Developmental biology of plants and animals , development and differentiation in microorganismsasal honarpour 1 , Ahmad Majd 2 , reza mirfakhraie 3 , maryam rahimi 4 , Sayedhamid jamaldini 5
1 - Department of Genetics, North Tehran Branch, Iran Islamic Azad University, Tehran, Iran
2 - Professor of Biology, Faculty of Biological Sciences, Islamic Azad University, Tehran-North Branch
3 - Departments of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of
Medical Sciences, Tehran, Iran
4 - Medical Genomics Research Center, Tehran Medical Sciences, Islamic Azad University,
Tehran, Iran
5 - Department of Gynecology and Obstetrics, School of Medicine, Iran University of Medical
Sciences, Tehran, Iran
Keywords: preeclampsia, ACVR2A, polymorphism, rs1424941,
Abstract :
Preeclampsia is one of the most common diseases associated with pregnancy in humans, which is associated with high blood pressure, and is considered one of the main causes of fetal and maternal mortality. This disease occurs in all races, and is only specific to pregnancy.In this study, we investigated the role of ACVR2A rs1424941 gene polymorphism in preeclamptic patients and controls. DNA extraction was performed on 400 peripheral blood samples of people with preeclampsia and healthy people, TP-ARMS-PCR method was used to determine the genotype of the samples from preeclamptic and normal pregnant women. The results of association analysis indicated that rs1424941 variant, heterozygous AG genotype was associated with increased risk of PE. P=0.04 the present study for the first time confirmed the role of ACVR2A rs1424941 polymorphism in the pathogenesis of PE in Iranian population. However, repeated studies in different ethnicities are necessary to confirm the role of rs1424941 genotype on susceptibility to preeclampsia.
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