Effect of bromocriptine on thyroid hormone levels in human blood

Subject Areas : Developmental biology of plants and animals , development and differentiation in microorganisms

Siyamak Nayebi ¹ , Reza Hajihosseini ²

1 - ,Department of Biochemistry,, Payam Noor University, Tehran, Iran
2 - Professor , Department of Biochemistry,, Payam Noor University, Tehran, Iran

Received: 2022-03-12 Accepted : 2022-04-09 Published : 2022-11-22

Keywords: Hormones, thyroid, bromocriptine, Dopamine,

Abstract :

Drugs prescribed for the treatment of various diseases have side effects on various organs, including thyroid gland. Bromocriptine mesylase (bromocriptine) is a semi-synthetic alkaloid with high dopaminergic activity that directly stimulates dopamine neurotransmitters. In this study, samples were taken from two groups of patients over a period of 10 months. The first group included 25 normal clients and individuals which was known as euthyroid (with normal thyroid function with normal levels of thyroid gland) in the age range of 30-37 years (samples 1 to 25) and the second group included 25 other people with the same condition in the age range of 38-45 years (samples 26 to 50). Both groups used only bromocriptine tablets as drug treatment with the dose of 5mg/day in a period of at least 6 months. Based on the results, the levels of T3 and T4 hormones decreased significantly after treatment with bromocriptine. TSH levels showed a relative decrease in both age groups after treatment with bromocriptine. In this study, the effectiveness of bromocriptine on the level of thyroid stimulating hormone (TSH) and thyroid hormones T4, T3 and T-Uptake was confirmed by making statistically significant changes. Bromocriptine treatment appeared to affect two thyroid functions at two points, including the effect on TSH production by the hypothalamic axis as well as the disruption of T4 to T3 conversion in peripheral tissues.