بررسی بالینی اثربخشی داروهای یونانی بر بیماری های پوستی
Subject Areas : Journal of Medicinal Herbs, "J. Med Herb" (Formerly known as Journal of Herbal Drugs or J. Herb Drug)موشیر انصاری 1 , نسرین جهان 2 , عبید علی 3 , تنزیل احمد 4
1 - Department of Ilmul Advia, Anjuman i-islam, Dr. MIJTU Medical College, Mumbai-400061, Maharshtra, India.
2 - Department. of Ilmul Advia, National Institute of Unani Medicine, Bangalore-560091, India
3 - Department of Kulliyat, HMS Unani Medical College, Post Marlur, Tumakuru, Karnataka 572105, India.
4 - Department of Moalejat, Ajmal khan Tibbiya College, AMU, Aligarh, Uttar Pradesh, India.
Keywords: Systematic Review, Unani, Skin diseases, Health-related outcomes,
Abstract :
Background & Aim: Throughout the past three decades, scientific attention has been increased in examining Unani drugs for a potential therapeutic or preventive agent in the management of a number of health disorders in general and skin disorder in particular. The purpose of this systematic review is to analyze and categorize the current state of scientific evidence from clinical studies regarding the efficacy of Unani drugs in skin diseases. Experimental: Electronic and non-electronic systematic searches were carried out to identify all relevant clinical research on Unani drugs. Reference lists of articles that met the inclusion criteria were searched. Only studies reported in English were reviewed. Studies on single Unani drugs and compound formulations in various skin diseases were included, in accordance with the PRISMA statement that included studies must measure a physiological and/or a behavioral outcome. Results: The studies that met our inclusion criteria are effects of Unani drugs on Acne (n=5), Melasma (n=2), Pityriasis (n=1), Vitiligo (n=2), Urticaria (n=2), Ring worm (n=2), Psoriasis (n= 3), Eczema (n = 2), and Scabies (n = 1). The data from these studies support the efficacy of Unani drugs as compared to placebo and standard drugs in improving Acne, Melasma, Pityriasis, Vitiligo, Urticaria, Ring worm, Psoriasis, Eczema and Scabies. Recommended applications/industries: Findings from initial clinical trials suggest that Unani drugs may improve the clinical manifestations of skin diseases. However, larger multi-site clinical trials are needed to extend these preliminary findings.
Akhtar, S., Khan, B.D. and Aleem, S. 2011. Evaluation of Itrifal-e- Shahatra and Roghan-e- Babchi in Case of Daa-us-Sadaf. Hippocratic Journal of Unani Medicine, 6:11-22.
Al-Hoqail, I.A. 2013. Epidemiological spectrum of common dermatological conditions of patients attending dermatological consultations in Al-Majmaah Region (Kingdom of Saudi Arabia).Journal of Taibah University Medical Sciences, 8(1): 31–37.
Ali, S.M., Alam, M. and Jamal, A. 2006. Clinical evaluation of the efficacy of polyherbal Unani formulations in scabies. Indian Journal of Traditional Knowledge, 5(2): 220-223.
Ara, I., Khan, N.H., Bukhari, B. and Ara, N. 2014. Efficacy of Marham-e-Rall and Quars Musaffi Khoon (Kit Medicine) in Acne Vulgaris I. International Journal of Advanced Ayurveda, Yoga, Unani, Siddha and Homeopathy, 3(1):189-192.
Arzani, 2002. Mufarreh-ul-Quloob. HS Offset Press, New Delhi.
Chauhan, S. 2013. An overview on blood purifier. International Research Journal of Pharmacy, 4(9):8-10.
Gauri, M., Ahmed, T., Khan, M.S. and Ali, S.J. 2015. Therapeutic Evaluation of Unani Herbal Medicine for Topical Application (Zimad of Tukhme Turb, Tukhme Karafs and Sirka) in Melasma (Kalaf) - A Single Blind Randomized Controlled Study. International Journal of Scientific Research, 4(12): 38-41.
Grills, N., Grills, C., Spelman, T., Stoove, M., Hellard, M. and El-Hayek, C. 2012. Prevalence survey of dermatological conditions in mountainous north India. International Journal of Dermatology, 51(5): 579-587.
Hasan, T.S.S., Aleem, S. and Tabassum, L. 2011. Clinical evaluation of efficacy of Majoon Ushba and Marham Gulabi in Qooba. Indian Journal of Traditional Knowledge, 10:702-705.
Ibn Sina, 2007. Al Qanoon Fit Tib. Vol. I–V. Idara Kitabul Shifa, New Delhi.
Joel, J.J., Jose, N. and Shastry, C.S. 2013. Patterns of Skin Disease and Prescribing Trends in Rural India. Scholars Academic Journal of Pharmacy, 2(4): 304-309.
Kalam, M.A. and Ahmad, G. 2016. Medicinal importance of climbers used in Unani system of medicine. In: Shahzad, Anwar, Sharma, Shiwali, Siddiqui, and Saeed A. (Eds.), Biotechnological Strategies for the Conservation of Medicinal and Ornamental Climbers. Springer International Publishing, Switzerland.
Karimkhani, C.,Dellavalle, R.P., Coffeng L.E., Flohr, C., Hay, R.J., Langan, S.M., Nsoesie, E.O., Ferrari, A.J., Erskine, H.E., Silverberg, J.I., Vos, T. and Naghavi, M. 2017.Global skin disease morbidity and mortality: An update from the global burden of disease study 2013. Journal of the American Academy of Dermatology, 153(5): 406-412.
Khan, S., Siddiqui, M.M.H. and Aleem, S. 2009. Effect of Psoralia corylifolia Linn. and Marhame Gulabi in da-al-sadaf. Indian Journal of Traditional Knowledge, 8: 425-430.
Lone, A.H., Ahmad, T., Anwar, M. and Ahmad, J. 2011. Therapeutic evaluation of a Unani herbomineral formulation in chronic urticaria. Journal of Pakistan Association of Dermatologists, 21: 33-37.
Lone, A.H., Ahmad, T. and Naiyar, A.H. 2011.Clinical evaluation of efficacy of Majoon Ushba and Roghane Hindi in the management of psoriasis: A randomized single-blind, placebo-controlled study. Journal of Ayurveda and Integrative Medicine, 2(1): 26–31.
Lone, A.H., Ahmad, T., Anwar, M, Sofi, G. and Naiyar, AH. 2011. Clinical evaluation of efficacy and safety of a polyherbal formulation in acne vulgaris. Egyptian Dermatology Online Journal, 7 (2): 2.
Lone, A.H., Ahmad, T., Anwar, M. and Sofi, G. 2012. Clinical Efficacy and Safety of a Pharmacopial Polyherbal Unani Formulation in Pityriasis Versicolor: A Comparative Randomized Single-Blind Study. The Journal of Alternative and Complementary Medicine, 18(10): 978-982.
Masehi, 2008. Kitabul Mia, Volume 1. Central Council for Research in Unani Medicine, Govt. of India, Ministry of Health and Family Welfare, Department of AYUSH, New Delhi.
Mathers, C.D. and Loncar, D. 2006. Projections of Global Mortality and Burden of Disease from 2002 to 2030. Public Library of Science Medicine, 3(11): 442.
Mobeen, A., Ahmad, T. and Ansari, AN. 2012. Therapeutic Evaluation of Joshanda Mundi and Marham Qooba in Dermatophytosis: A randomised controlled trial. Journal of Research in Unani Medicine, 1(1): 36-41.
Mohd, M., Tarique, M. andSiddiqui, M.A. 2014 Therapeutic efficacy of majoon atrilaal and local application of sheetraj, Nila Tootiya in the management of Bars (Vitiligo). American Journal of Pharmacy & Health Research, 2 (10).
Nawab, M., Mannan, A. and Siddiqui, M. 2008. Evaluation of the clinical efficacy of unani formulation on eczema. Indian Journal of Traditional Knowledge, 7: 341-344.
Nilugal, K.C., Chittur, A.I., Nishaidevi and Ugandar, R.E. 2015. Antimicrobial potentiality of petiole extracts of Apium graveolens L. World Journal of Pharmacy and Pharmaceutical Sciences, 4(4): 216-231.
Qamri, A.M.H. 2008. Ghina Muna Ma Tarjuma Minhajul Ilaj. Central Council for Research in Unani Medicine, New Delhi.
Qarshi, M.H. 2011. Jameul Hikmat. Idarah Kitabul Shifa, New Delhi.
Quamri, M.A., Naila., Abrar, S., Rahman, A, and Siddiqui, MA. 2009. Clinical study and management of basoor labniya (Acne vulgaris) with unani formulation. Indian Journal of Unani Medicine, 2: 33-38.
Qureshi, 1998. Muqadma Ilmul Advia. Aijaz publishinghouse, Delhi.
Rahman, S.Z., Khan, R.A. and Latif, A., 2008. Importance of pharmacovigilance in Unani system of medicine. Indian Journal of Pharmacology, 40: 17–20.
Razi. 1991. Kitabul Mansuri. Central council for research in unani medicine.19: 51-53. New Delhi.
Shamsi, Y., Kumar, H., Tamanna, S.A. and Khan, E.A. 2006. Effect of polyherbal unani formulation on chronic urticaria. Indian Journal of Traditional Knowledge, 5(2): 279-283.
Siddiqui, M.A., Ahmad, T. and Amjad, M. 2010. Therapeutic evaluation of Unani formulation in eczema. Indian Journal of Unani Medicine, 3(2), 89-96.
Stephanie, 2017. Medications for Skin Conditions. Available on Internet at: https://www.webmd.com/skin-problems-and-treatments / medications-skin-conditions.
Sultana, S., Zulkifle, M., Ansari, A.H. and Shahnawaz, 2015. Efficacy of local application of an Unani formulation in acne vulgaris.Ancient Science of Life, 35(2): 124–128.
Tabasum, H., Ahmad, T., Anjum, F. and Rehman, H. 2014. The effect of Unani anti acne formulation (Zimade Muhasa) on acne vulgaris: A single blind, randomized, controlled clinical trial. Journal of Pakistan Association of Dermatologists, 24 (4): 319-326.
Tabri, 1997. Moalijate Buqratiya.Central Council for Research in Unani Medicine, Govt. of India, Ministry of Health and Family Welfare, Department of AYUSH, New Delhi.
Tanzeel A., Siddiqui M.M.H., Sofi, G. and Zubair, M. 2011. Therapeutic evaluation of safoofe bars in the management of Vitiligo - A preliminary study, Unani Research, Pharmacognosy Magazine, 1(1): 39-42.
Tyagi, S., Chirag, P., Dhruv, M., Ishita, M.M., Gupta, AK., Usman, M.R.M., Nimbiwal. B. andMaheshwari, R.K. 2013. Medical benefits of apium graveolens (celery herb).Journal of Drug Discovery and Therapeutics, 1 (5): 36-38.
Zarnigarand Riaz, A. 2011. Evaluation of Shooneez (Nigella sativa) and Sirka(Sugarcane vinegar) in Kalaf (Melasma). Hippocratic Journal of Unani Medicine, 6(4): 145-149.
Akhtar, S., Khan, B.D. and Aleem, S. 2011. Evaluation of Itrifal-e- Shahatra and Roghan-e- Babchi in Case of Daa-us-Sadaf. Hippocratic Journal of Unani Medicine, 6:11-22.
Al-Hoqail, I.A. 2013. Epidemiological spectrum of common dermatological conditions of patients attending dermatological consultations in Al-Majmaah Region (Kingdom of Saudi Arabia).Journal of Taibah University Medical Sciences, 8(1): 31–37.
Ali, S.M., Alam, M. and Jamal, A. 2006. Clinical evaluation of the efficacy of polyherbal Unani formulations in scabies. Indian Journal of Traditional Knowledge, 5(2): 220-223.
Ara, I., Khan, N.H., Bukhari, B. and Ara, N. 2014. Efficacy of Marham-e-Rall and Quars Musaffi Khoon (Kit Medicine) in Acne Vulgaris I. International Journal of Advanced Ayurveda, Yoga, Unani, Siddha and Homeopathy, 3(1):189-192.
Arzani, 2002. Mufarreh-ul-Quloob. HS Offset Press, New Delhi.
Chauhan, S. 2013. An overview on blood purifier. International Research Journal of Pharmacy, 4(9):8-10.
Gauri, M., Ahmed, T., Khan, M.S. and Ali, S.J. 2015. Therapeutic Evaluation of Unani Herbal Medicine for Topical Application (Zimad of Tukhme Turb, Tukhme Karafs and Sirka) in Melasma (Kalaf) - A Single Blind Randomized Controlled Study. International Journal of Scientific Research, 4(12): 38-41.
Grills, N., Grills, C., Spelman, T., Stoove, M., Hellard, M. and El-Hayek, C. 2012. Prevalence survey of dermatological conditions in mountainous north India. International Journal of Dermatology, 51(5): 579-587.
Hasan, T.S.S., Aleem, S. and Tabassum, L. 2011. Clinical evaluation of efficacy of Majoon Ushba and Marham Gulabi in Qooba. Indian Journal of Traditional Knowledge, 10:702-705.
Ibn Sina, 2007. Al Qanoon Fit Tib. Vol. I–V. Idara Kitabul Shifa, New Delhi.
Joel, J.J., Jose, N. and Shastry, C.S. 2013. Patterns of Skin Disease and Prescribing Trends in Rural India. Scholars Academic Journal of Pharmacy, 2(4): 304-309.
Kalam, M.A. and Ahmad, G. 2016. Medicinal importance of climbers used in Unani system of medicine. In: Shahzad, Anwar, Sharma, Shiwali, Siddiqui, and Saeed A. (Eds.), Biotechnological Strategies for the Conservation of Medicinal and Ornamental Climbers. Springer International Publishing, Switzerland.
Karimkhani, C.,Dellavalle, R.P., Coffeng L.E., Flohr, C., Hay, R.J., Langan, S.M., Nsoesie, E.O., Ferrari, A.J., Erskine, H.E., Silverberg, J.I., Vos, T. and Naghavi, M. 2017.Global skin disease morbidity and mortality: An update from the global burden of disease study 2013. Journal of the American Academy of Dermatology, 153(5): 406-412.
Khan, S., Siddiqui, M.M.H. and Aleem, S. 2009. Effect of Psoralia corylifolia Linn. and Marhame Gulabi in da-al-sadaf. Indian Journal of Traditional Knowledge, 8: 425-430.
Lone, A.H., Ahmad, T., Anwar, M. and Ahmad, J. 2011. Therapeutic evaluation of a Unani herbomineral formulation in chronic urticaria. Journal of Pakistan Association of Dermatologists, 21: 33-37.
Lone, A.H., Ahmad, T. and Naiyar, A.H. 2011.Clinical evaluation of efficacy of Majoon Ushba and Roghane Hindi in the management of psoriasis: A randomized single-blind, placebo-controlled study. Journal of Ayurveda and Integrative Medicine, 2(1): 26–31.
Lone, A.H., Ahmad, T., Anwar, M, Sofi, G. and Naiyar, AH. 2011. Clinical evaluation of efficacy and safety of a polyherbal formulation in acne vulgaris. Egyptian Dermatology Online Journal, 7 (2): 2.
Lone, A.H., Ahmad, T., Anwar, M. and Sofi, G. 2012. Clinical Efficacy and Safety of a Pharmacopial Polyherbal Unani Formulation in Pityriasis Versicolor: A Comparative Randomized Single-Blind Study. The Journal of Alternative and Complementary Medicine, 18(10): 978-982.
Masehi, 2008. Kitabul Mia, Volume 1. Central Council for Research in Unani Medicine, Govt. of India, Ministry of Health and Family Welfare, Department of AYUSH, New Delhi.
Mathers, C.D. and Loncar, D. 2006. Projections of Global Mortality and Burden of Disease from 2002 to 2030. Public Library of Science Medicine, 3(11): 442.
Mobeen, A., Ahmad, T. and Ansari, AN. 2012. Therapeutic Evaluation of Joshanda Mundi and Marham Qooba in Dermatophytosis: A randomised controlled trial. Journal of Research in Unani Medicine, 1(1): 36-41.
Mohd, M., Tarique, M. andSiddiqui, M.A. 2014 Therapeutic efficacy of majoon atrilaal and local application of sheetraj, Nila Tootiya in the management of Bars (Vitiligo). American Journal of Pharmacy & Health Research, 2 (10).
Nawab, M., Mannan, A. and Siddiqui, M. 2008. Evaluation of the clinical efficacy of unani formulation on eczema. Indian Journal of Traditional Knowledge, 7: 341-344.
Nilugal, K.C., Chittur, A.I., Nishaidevi and Ugandar, R.E. 2015. Antimicrobial potentiality of petiole extracts of Apium graveolens L. World Journal of Pharmacy and Pharmaceutical Sciences, 4(4): 216-231.
Qamri, A.M.H. 2008. Ghina Muna Ma Tarjuma Minhajul Ilaj. Central Council for Research in Unani Medicine, New Delhi.
Qarshi, M.H. 2011. Jameul Hikmat. Idarah Kitabul Shifa, New Delhi.
Quamri, M.A., Naila., Abrar, S., Rahman, A, and Siddiqui, MA. 2009. Clinical study and management of basoor labniya (Acne vulgaris) with unani formulation. Indian Journal of Unani Medicine, 2: 33-38.
Qureshi, 1998. Muqadma Ilmul Advia. Aijaz publishinghouse, Delhi.
Rahman, S.Z., Khan, R.A. and Latif, A., 2008. Importance of pharmacovigilance in Unani system of medicine. Indian Journal of Pharmacology, 40: 17–20.
Razi. 1991. Kitabul Mansuri. Central council for research in unani medicine.19: 51-53. New Delhi.
Shamsi, Y., Kumar, H., Tamanna, S.A. and Khan, E.A. 2006. Effect of polyherbal unani formulation on chronic urticaria. Indian Journal of Traditional Knowledge, 5(2): 279-283.
Siddiqui, M.A., Ahmad, T. and Amjad, M. 2010. Therapeutic evaluation of Unani formulation in eczema. Indian Journal of Unani Medicine, 3(2), 89-96.
Stephanie, 2017. Medications for Skin Conditions. Available on Internet at: https://www.webmd.com/skin-problems-and-treatments / medications-skin-conditions.
Sultana, S., Zulkifle, M., Ansari, A.H. and Shahnawaz, 2015. Efficacy of local application of an Unani formulation in acne vulgaris.Ancient Science of Life, 35(2): 124–128.
Tabasum, H., Ahmad, T., Anjum, F. and Rehman, H. 2014. The effect of Unani anti acne formulation (Zimade Muhasa) on acne vulgaris: A single blind, randomized, controlled clinical trial. Journal of Pakistan Association of Dermatologists, 24 (4): 319-326.
Tabri, 1997. Moalijate Buqratiya.Central Council for Research in Unani Medicine, Govt. of India, Ministry of Health and Family Welfare, Department of AYUSH, New Delhi.
Tanzeel A., Siddiqui M.M.H., Sofi, G. and Zubair, M. 2011. Therapeutic evaluation of safoofe bars in the management of Vitiligo - A preliminary study, Unani Research, Pharmacognosy Magazine, 1(1): 39-42.
Tyagi, S., Chirag, P., Dhruv, M., Ishita, M.M., Gupta, AK., Usman, M.R.M., Nimbiwal. B. andMaheshwari, R.K. 2013. Medical benefits of apium graveolens (celery herb).Journal of Drug Discovery and Therapeutics, 1 (5): 36-38.
Zarnigarand Riaz, A. 2011. Evaluation of Shooneez (Nigella sativa) and Sirka(Sugarcane vinegar) in Kalaf (Melasma). Hippocratic Journal of Unani Medicine, 6(4): 145-149.
