Journal of Applied Chemical Research: 3 (3)

Open Access Article

1 - Construction and Characterization of polyvinyl alcohol-sodium alginate magnetic hydrogel for use in release of famotidine
Mahdiyeh Poorgholam Masoud Mokhtary mohammad alikarami

Abstract Polyvinyl alcohol-sodium alginate magnetic hydrogel was prepared using K2S2O8 in aqueous media in the presence of N,N′-methylenebisacrylamide and Fe3O4 nanoparticles. The magnetic polyvinyl alcohol-sodium alginate (nano-Fe3O4/PVA-SA) hydrogel was characteriz More

Abstract Polyvinyl alcohol-sodium alginate magnetic hydrogel was prepared using K2S2O8 in aqueous media in the presence of N,N′-methylenebisacrylamide and Fe3O4 nanoparticles. The magnetic polyvinyl alcohol-sodium alginate (nano-Fe3O4/PVA-SA) hydrogel was characterized by FTIR, SEM, and EDX methods. Also, magnetic characterization of the synthesized nanoFe3O4/PVA-SA hydrogel was identified by vibrating sample magnetometer (VSM) method. Then, loading and release of famotidine drug was studied by nano-Fe3O4/PVA-SA hydrogel. The FT-IR results confirmed the formation of nano-Fe3O4/PVA-SA hydrogel. The effects of temperature and pH on the loading and release of famotidine drug in gelatin-polyvinylalcohol magnetic hydrogel were studied. The polyvinyl alcohol-sodium alginate magnetic hydrogel is sensitive to pH and temperature and provides the controlled release of famotidine. The results showed that the highest drug loading was achieved at 37 °C after 6 hours. Farther more, the highest drug release rate was obtained after 6 hours at 37 °C at pH = 2 with 57.95 ppm. Manuscript profile

Open Access Article

2 - Photocatalytic Degradation of Phenol in Water Solution by Phosphotungstic Acid on TiO2/ZnO Nanoparticles as Supporting Solid
Marzieh Nasiriyan معصومه طباطبایی Seyed Abolghasem Mirhoseini

A Keggin-type heteropolyoxometalate (H3PW12O40) supported on TiO2/ZnO nanoparticles was used for the degradation of phenol under UV light and H2O2 as oxidant. Based on the results, heterogenization of H3PW12O40 on TiO2/ZnO could improve the photocatalytic process and More

A Keggin-type heteropolyoxometalate (H3PW12O40) supported on TiO2/ZnO nanoparticles was used for the degradation of phenol under UV light and H2O2 as oxidant. Based on the results, heterogenization of H3PW12O40 on TiO2/ZnO could improve the photocatalytic process and could be considered an appropriate heterogonous photocatalyst in the removal of phenol from aqueous solutions in the presence of hydrogen peroxide. Degradation of phenol in the presence of the H3PW12O40/TiO2/ZnO could lead to the disappearance of approximately 95% of phenol under UV irradiation and optimized condition. In the same experiment H3PW12O40 as a homogenous catalyst, removed 70% phenol and the heterogeneous TiO2/ZnO catalyst removed less than 70% phenol from the water solution in the same conditions. Manuscript profile

Open Access Article

3 - Synthesis of SiO2 Nano particles-Dimethyl Malonate Polymer
banafsheh gorji allahgholi ghasri allahgholi ghasri

The goal of this research is synthesis of hybrid inorganic-organic microstructure to form a monolayer with anti-reflective properties. Dimethyl Malonate –Silica gel (DMM-SiO2) composite were synthesized by chemical method from dimethyl malonate (DMM) and silica gel p More

The goal of this research is synthesis of hybrid inorganic-organic microstructure to form a monolayer with anti-reflective properties. Dimethyl Malonate –Silica gel (DMM-SiO2) composite were synthesized by chemical method from dimethyl malonate (DMM) and silica gel particles with a diameter ~34 nm. The anionic polymerization was applied for the preparation of composite. DMM as monomer polymerizes upon reacting with an initiator (OHin H2O) and terminate by a terminator (H+ in HCl). We modify the anionic polymerization reaction by adding silica gel nanoparticles before initiating polymerization. Variables including SiO2 concentration, surfactant concentration, DMM/SiO2 ratio, and pH of solution have been investigated. The optimal synthesis conditions were obtained by Box-Behnken design (BBD). The results show that reaction should be carried out at ambient temperature and pH 4.5. Sodium dodecyl sulfate (SDS) as surfactant concentration, SiO2 concentration and DMM/SiO2 ratio should be 5 mmol, 2 w.t% and 4.2g/1g, respectively. DMM-SiO2 composite were characterized by Scanning Electron Microscopy (SEM), and Thermogravimetry Analysis (TGA). Manuscript profile

Open Access Article

4 - Preconcentration and Determination of Theophylline in Water Samples using Magnetic Nano-Cellulose with Dispersive Solid Phase Extraction
Parastoo Molaei ali moghimi Shahin Ahmadi seyedali sobhanian

Theophylline (1,3-dimethyl-2,3,6,7-tetrahydro-1-hydrogen-purine-6,2-dione) is a bronchodilator drug used in the treatment of asthma and chronic obstructive pulmonary disease (COPD). Due to the narrow therapeutic strip of this drug, it is important to measure its blood l More

Theophylline (1,3-dimethyl-2,3,6,7-tetrahydro-1-hydrogen-purine-6,2-dione) is a bronchodilator drug used in the treatment of asthma and chronic obstructive pulmonary disease (COPD). Due to the narrow therapeutic strip of this drug, it is important to measure its blood level.To achieve a simple, safe and sensitive method based on dispersive solid phase extraction (DSPE) using magnetite nanoparticles covered with nanocellulose and beta-cyclodextrin for preconcentration and measurement of theophylline in aqueous samples and its validation, this method was used. In this research, variables affecting the extraction such as pH, ionic strength, and amount of adsorbent, temperature, time, limit volume and type of solvent were optimized. After extraction, the adsorbent was easily separated from the aqueous sample using an external magnetic field without filtration or centrifugation. The results showed that optimum conditions were obtained with pH=5, 1 mg of sodium chloride, 0.2 g of adsorbent with a capacity of 0.53 mg/g, temperature of 40 degrees Celsius, 20 minutes of contact between the adsorbent and the sample and 5 mL of methanol as the desorption solvent. In optimal conditions, the suitable concentration factor is 12, low detection limit (0.17 mg/L), wide linear range and in accordance with the therapeutic strip of the drug (5-50 mg/L), good correlation coefficient (R2=0.9991) and good accuracy (RSD=1.03%) was obtained.Urine sample was used to validate the above method. Also, it was found that the proposed method is suitable, efficient and usable for measuring of theophylline. Manuscript profile

Open Access Article

5 - Investigation of Fe-Cu-Sr/ γ-Al2O3 catalyst performance in Fisher- Tropsch synthesis: Pressure effect
Marziyeh Rahimi Mashkaleh Yahya Zamani sahar baniyaghoob Ensiyeh Ganji Babakhani

Fischer-Tropsch synthesis (FTS) is conducted on the catalysts such as Al2O3, SiO2, TiO2 and ZrO2 supported with metals like Co, Fe or Ru. While hydrogen to CO ratio is low, the Iron supported catalysts are more useful to produce alkenes, branched hydrocarbons and oxygen More

Fischer-Tropsch synthesis (FTS) is conducted on the catalysts such as Al2O3, SiO2, TiO2 and ZrO2 supported with metals like Co, Fe or Ru. While hydrogen to CO ratio is low, the Iron supported catalysts are more useful to produce alkenes, branched hydrocarbons and oxygenates due to Iron's water-gas-shift (WGS) activity. The aim of this article is to produce C5+ hydrocarbon product from synthetic gas using Fe-Cu-Sr/ γ-Al2O3 nano-sized catalyst. The nano iron-based catalyst was synthesized by wet impregnation method. The synthesized catalyst (18Fe/4Cu/2Sr/ γ-Al2O3) was characterized by XRD, BET, ICP, SEM and H2-TPR techniques. Effect of reaction pressure on the product selectivity and catalyst activity was investigated in CO hydrogenation reaction. The nano catalyst was loaded in a fixed-bed reactor and tested in pressure of 16 and 20 atm, at temperature of 290 oC, with H2/CO ratio of 1 and GHSV of 2 l.h-1.g cat-1. The results demonstrated that with increasing reaction pressure, the CO conversion and C5+ selectivity increased from 63.8% and 44.03% to 78.3% and 46.2%, respectively. Manuscript profile

Open Access Article

6 - Synthesis and molecular docking studies of 4H-chromene derivatives as a calcium channel blocking agent
somayeh makarem yalda kashkooli Afshin Rajabi Khorrami Shabnam nadjafi

Voltage-gated Ca2+ channels play a vital role in the transmission of electrical signals by temporarily increasing intracellular Ca2+ levels and exerting an action potential on the cell surface membrane. As a blocker of calcium channels, nimodipine specifically blocks L- More

Voltage-gated Ca2+ channels play a vital role in the transmission of electrical signals by temporarily increasing intracellular Ca2+ levels and exerting an action potential on the cell surface membrane. As a blocker of calcium channels, nimodipine specifically blocks L-type calcium channels, which are present in smooth muscle cells in blood vessels. By blocking these channels, nimodipine prevents calcium from entering the cells, resulting in relaxation and dilation of the blood vessels. In this way, several 4H-chromene derivatives were obtained through electro synthesis in propanol, using electrons as a catalyst to generate propanol anion as a base. This process involved obtaining malononitrile anion, which readily underwent Knovenagel condensation with aromatic aldehydes, followed by the reaction of the active methylene of dimedione with the electrophile C=C of the intermediate. Finally, the expected product was o−btained through cyclisation and tautomerization. The effect of current, solvent, and anode type were studied, and it was observed that the optimized current, solvent, and anode for the synthesis of nanoparticles of 4H-chromene were 50 mA/cm2, propanol, and a magnesium anode in an undivided cell at room temperature. The proposed method produces 4H-chromene directly from initial compounds in a mild and safe condition. All synthesized compounds were screened through molecular docking studies, which utilized the crystal structure of CavAb. Compound 8f exhibited the minimum binding energy and good affinity toward the active pocket of CavAb compared to nimodipine as a calcium channel blocking agent. Manuscript profile

XML

List of Articles