Construction and Characterization of polyvinyl alcohol-sodium alginate magnetic hydrogel for use in release of famotidine
Subject Areas : Medicinal Chemistry
Mahdiyeh Poorgholam
1
(Department of Chemistry, Rasht Branch, Islamic Azad University, Rasht, Iran)
Masoud Mokhtary
2
(Department of Chemistry, Rasht Branch, Islamic Azad University, PO Box 41325-3516, Rasht, IRAN)
mohammad alikarami
3
(Department of Chemistry, Ilam Branch, Islamic Azad University, Ilam, Iran.)
Keywords: Sodium alginate, Polyvinylalcohol, Magnetic hydrogel, Famotidine, Drug release,
Abstract :
Abstract Polyvinyl alcohol-sodium alginate magnetic hydrogel was prepared using K2S2O8 in aqueous media in the presence of N,N′-methylenebisacrylamide and Fe3O4 nanoparticles. The magnetic polyvinyl alcohol-sodium alginate (nano-Fe3O4/PVA-SA) hydrogel was characterized by FTIR, SEM, and EDX methods. Also, magnetic characterization of the synthesized nanoFe3O4/PVA-SA hydrogel was identified by vibrating sample magnetometer (VSM) method. Then, loading and release of famotidine drug was studied by nano-Fe3O4/PVA-SA hydrogel. The FT-IR results confirmed the formation of nano-Fe3O4/PVA-SA hydrogel. The effects of temperature and pH on the loading and release of famotidine drug in gelatin-polyvinylalcohol magnetic hydrogel were studied. The polyvinyl alcohol-sodium alginate magnetic hydrogel is sensitive to pH and temperature and provides the controlled release of famotidine. The results showed that the highest drug loading was achieved at 37 °C after 6 hours. Farther more, the highest drug release rate was obtained after 6 hours at 37 °C at pH = 2 with 57.95 ppm.
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