فهرس المقالات Inclusion complex

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  1 - Inclusion Complex of β-CD-DZ as a nanocarrier: Preparation, Spectroscopic characterization, Thermodynamic parameters and molecular modelling Study
  Fatemeh Fateminasab Abdol-Khalegh Bordbar
  The β-CD-DZ inclusion complex was prepared via freeze-drying method and characterized by using various spectroscopic techniques. The phase solubility diagram and Job plot showed the formation of a soluble complex of AL type (1:1 stoichiometric IC) with improved sol أکثر

  The β-CD-DZ inclusion complex was prepared via freeze-drying method and characterized by using various spectroscopic techniques. The phase solubility diagram and Job plot showed the formation of a soluble complex of AL type (1:1 stoichiometric IC) with improved solubility and stability. The thermodynamic parameters for the β-CD-DZ IC formation were determined and analyzed on basis of involved driving forces. The results showed the reaction process in mainly entropy driven and endothermic that assigned the predominant role of hydrophobic interaction in the formation of β-CD-DZ complex. In conclusion, a comprehensive computational study has been done on formation process of β-CD-DZ IC using molecular docking methods. In case of β-CD-DZ IC, the results of thermodynamic parameters, molecular docking confirmed stable complex formation between β-CD-DZ and also DZ included into a narrow site of inner cavity of β-CD. تفاصيل المقالة
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  2 - Studies on inclusion complexes of 2-[Substituted arylideamino]-1, 3, 4-thiadiazino [6,5b]indole with β- Cyclodextrin
  Sunakar Panda Jagat Tripathy
  Inclusion complexes of 2-[Arylidenamino]-1,3,4-thiadiazino[6,5b]indoles have been prepared with β-cyclodextrin so as to increase the solubility of these compounds in polar medium which may increase theirbioaccessibility. The formation of inclusion complexes is know أکثر

  Inclusion complexes of 2-[Arylidenamino]-1,3,4-thiadiazino[6,5b]indoles have been prepared with β-cyclodextrin so as to increase the solubility of these compounds in polar medium which may increase theirbioaccessibility. The formation of inclusion complexes is known from the study of changes in physical andspectral properties of the compounds. The stability of the inclusion complexes has been studied by thedetermination of the thermodynamic parameters like change in free energy, change in enthalpy and change inentropy. Finally compounds and their inclusion complexes are screened for antibacterial and antioxidantactivities. It is found that both antibacterial and antioxidant activity of the compounds increase significantlyafter the inclusion complex formation. In addition, the presence of activating groups on arylidene unit furtherfavours inclusion complex formation and also stabilizes the same. تفاصيل المقالة
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  3 - Thermodynamic, spectral and antimicrobial activity of inclusion complexes of acridone and its oxime with β-cyclodextrin
  Swapna Sankar Nayak Sunakar Panda
  One of the methods to enhance bio-accessibility of drugs like Acridone and its oxime is toform inclusion complexes with β-cyclodextrin. The formation of such complexes has beenconfirmed by changes in spectral characteristics and melting point data. The aqueous phas أکثر

  One of the methods to enhance bio-accessibility of drugs like Acridone and its oxime is toform inclusion complexes with β-cyclodextrin. The formation of such complexes has beenconfirmed by changes in spectral characteristics and melting point data. The aqueous phasesolubility studies reveal 1:1 stoichiometry between the compound and, β-cyclodextrin. The studyof thermodynamic parameters like ΔG, ΔH, ΔS indicates the inclusion complex formation to beexothermic and spontaneous. The study of antimicrobial activity of these compounds indicatesthat the microbes like E. coli and P. aeruginosa are susceptible and the susceptibility increasessignificantly after formation of inclusion complex. تفاصيل المقالة